Isolation and structural elucidation of euryjanicins B-D, proline-containing cycloheptapeptides from the Caribbean marine sponge Prosuberites laughlini.
Isolation and structural elucidation of euryjanicins B-D, proline-containing cycloheptapeptides from the Caribbean marine sponge Prosuberites laughlini.
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DOI：
10.1021/np9004135
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发表时间：
2009-09
影响因子：
5.1
通讯作者：
Rodríguez AD
中科院分区：
文献类型：
--
作者：
Vera B;Vicente J;Rodríguez AD
从波多黎各海绵Prosuberites laughlini中分离得到3个新的环肽euryjanicins B（2）、C（3）和D（4），并通过化学降解、ESIMS/MS和广泛的2D NMR方法对其结构进行了鉴定。当针对国家癌症研究所60肿瘤细胞系组进行测试时，所有纯化的分离物均显示出弱的细胞毒性。
Three new cyclic peptides, euryjanicins B (2), C (3), and D (4), have been isolated from the Puerto Rican marine sponge Prosuberites laughlini, and the structures were elucidated by chemical degradation, ESIMS/MS, and extensive 2D NMR methods. When tested against the National Cancer Institute 60 tumor cell line panel, all of the purified isolates displayed weak cytotoxicity.