Factors affecting depth of gastric ulcers.

Factors affecting depth of gastric ulcers.
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影响胃溃疡深度的因素。

DOI：
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发表时间：
1998
期刊：
The Tokai journal of experimental and clinical medicine
影响因子：
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通讯作者：
T. Miwa
T. Miwa
中科院分区：
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文献类型：
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作者：
T. Hasebe;S. Harasawa;T. Miwa

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目的 我们调查了不同深度胃溃疡的背景因素、临床特征和胃功能检查的差异。 患者和方法 受试者为68名被诊断为胃角部溃疡的患者（男性64名，女性4名）。溃疡根据以下深度进行分类： UL2（浅）溃疡至粘膜下层； UL3（中级），至固有肌层；和 UL4（深挖），超出固有肌层。通过内窥镜超声检查和/或普通内窥镜检查结果确定每个溃疡的深度。我们评估了临床特征、年龄、性别、吸烟习惯、饮酒、溃疡病史、幽门螺杆菌的存在、胃酸分泌、胃排空、血清胃泌素水平、治愈率和复发率。 结果 UL4型溃疡患者复发率较高，幽门螺杆菌感染发生率也明显较高。胃酸过多且目前吸烟或饮酒的患者患 UL4 型溃疡的可能性明显高于 UL2 或 3 型溃疡。此外，人们认识到复发、顽固性和深挖溃疡之间存在密切关系。溃疡深度与以下任何因素均无显着相关性：1）患者的概况；包括性别和出血症状； 2）胃功能；包括胃排空和血清胃泌素水平。 结论 吸烟、饮酒、溃疡复发、胃酸过多和幽门螺杆菌感染是与深层溃疡相关的重要因素。
PURPOSE We investigated the differences in background factors, clinical features, and gastric function tests among gastric ulcers of various depths. PATIENTS AND METHODS The subjects were 68 patients (male 64, female 4) who were diagnosed as having a gastric ulcer at the angulus. The ulcers were classified according to depth based on the following: UL2 (shallow) ulceration to the submucosa; UL3 (intermediate), to the muscularis propria; and UL4 (deep excavation), beyond the muscularis propria. The depth of each ulcer was determined by endoscopic ultrasonography and/or ordinary endoscopic findings. We assessed clinical features, age, gender, smoking habit, alcohol consumption, ulcer history, presence of H. pylori, gastric acid secretion, gastric emptying, serum gastrin level, healing rate, and recurrence rate. RESULTS Patients with UL4-type ulcers had a higher rate of recurrence and a significantly higher incidence of H. pylori infection. Patients with hyperacidity and currently smoking or consuming alcohol were significantly more likely to have UL4-type ulcers than of UL2 or 3 ulcers. Furthermore, a close relationship was recognized between recurrence, intractability and deeply excavated ulcers. Ulcer depth was not correlated significantly with any of the following factors: 1) patient's profile; including gender and hemorrhagic symptoms; 2) gastric function; including gastric emptying and serum gastrin levels. CONCLUSIONS Smoking, alcohol consumption, recurrence of ulcers, hyperacidity and H. pylori infections are important factors associated with deep ulcers.