OUTER HAIR CELL LOSS AND SUPPORTING CELL EXPANSION FOLLOWING CHRONIC GENTAMICIN TREATMENT
OUTER HAIR CELL LOSS AND SUPPORTING CELL EXPANSION FOLLOWING CHRONIC GENTAMICIN TREATMENT
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DOI：
10.1016/0378-5955(85)90121-2
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发表时间：
1985-01-01
期刊：
影响因子：
2.8
通讯作者：
FORGE, A
中科院分区：
文献类型：
--
作者：
FORGE, A
用薄切片和扫描电镜观察了慢性庆大霉素处理后Corti器中与外毛细胞（OHC）破坏及其被支持细胞取代相关的一系列变化。OHC的变化进程与相邻支持细胞的伴随扩张相匹配。侧膜毛细胞破裂。顶端碎片保留在网状层中，并被扩张的支持细胞包围。在Corti器官的表面没有形成大的裂口。相反，似乎毛细胞周围的紧密连接一直保持到在毛细胞体曾经占据的空间中新相邻的支持细胞之间建立连接。只有这样，OHC顶点才被破坏，碎片释放到盖层下空间。OHC变性过程的一些特征使人联想到细胞凋亡的受控细胞自毁现象。结果表明，毛细胞的损失和更换的过程可能会受到控制，使结构重组过程中的渗透性屏障的维护。
A sequence of changes in the organ of Corti associated with the destruction of outer hair cells (OHCs) and their replacement by supporting cells following chronic gentamicin treatment has been examined using thin-sections and SEM. The progression of change of OHCs was matched by concomitant expansion of adjacent supporting cells. Hair cells ruptured in the lateral membrane. The apical fragment was retained in the reticular lamina and became surrounded basally by the expanded supporting cells. No large breaches at the surface of the organ of Corti were formed. Rather, it appeared that the tight junctions around the hair cell were maintained until junctions were established between newly adjacent supporting cells in the space once occupied by the hair cell body. Only then was the OHC apex disrupted and the debris released into the sub-tectorial space. Some features of the OHC degeneration process were reminiscent of the controlled, cellular self-destruction phenomenon of apoptosis. The results suggest the possibility that the processes of hair cell loss and replacement may be controlled enabling maintenance of permeability barriers during structural reorganisation.