Effects of arsenite on central monoamines and plasmatic levels of adrenocorticotropic hormone (ACTH) in mice
Effects of arsenite on central monoamines and plasmatic levels of adrenocorticotropic hormone (ACTH) in mice
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DOI：
10.1016/s0378-4274(00)00240-x
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发表时间：
2000-09-30
影响因子：
3.5
通讯作者：
Jiménez-Capdeville, ME
中科院分区：
文献类型：
--
作者：
Delgado, JM;Dufour, L;Jiménez-Capdeville, ME
我们研究了慢性砷暴露对小鼠脑单胺和促肾上腺皮质激素（ACTH）血浆水平的影响。断奶后，小鼠在 9 周的时间内接受饮用水中的砷（0、20、40、60 或 100 ppm）。对不同脑区的单胺含量进行定量，对脑组织中的砷进行定量，并对血浆中的 ACTH 水平进行定量。脑内砷浓度高达 100 ng/g，与暴露水平显着相关，并对区域单胺水平产生轻微影响。血浆 ACTH 水平与髓质和笔中的去甲肾上腺素 (NE) 浓度显着相关，但与下丘脑 NE 水平无关。暴露于 20 ppm 浓度的组中 ACTH 水平显着较高。下丘脑多巴胺显示出与剂量相关的显着下降。这些结果表明，长期暴露于亚砷酸钠会导致中枢单胺的变化，这种变化与血浆 ACTH 的主要变化没有剂量依赖关系。 (C) 2000 Elsevier Science Ireland Ltd. 保留所有权利。
We studied the effects of chronic arsenic exposure on brain monoamines and plasma levels of adrenocorticotropic hormone (ACTH) of mice. After weaning, mice received arsenic (0, 20, 40, 60 or 100 ppm) in drinking water over a period of 9 weeks. Monoamine content was quantified in different brain regions, arsenic was quantified in brain tissue and ACTH levels in plasma. Brain arsenic concentrations up to 100 ng/g showed a significant correlation with exposure levels and produced slight modifications in regional monoamine levels. ACTH plasma levels were significantly associated with norepinephrine (NE) concentrations in the medulla and pens, but not with hypothalamic NE levels. ACTH levels were significantly higher in the group exposed to 20 ppm. Dopamine showed significant dose-related decreases in the hypothalamus. These results show that chronic sodium arsenite exposure produces changes in central monoamines, which are not associated on a dose-dependent basis with major alterations in plasma ACTH. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.