Receptor protein tyrosine phosphatase from stem cells to mature glial cells of the central nervous system
Receptor protein tyrosine phosphatase from stem cells to mature glial cells of the central nervous system
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DOI：
10.1385/jmn:29:3:241
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发表时间：
2006-01-01
影响因子：
3.1
通讯作者：
Harroch, Sheila
中科院分区：
文献类型：
--
作者：
Lamprianou, Smaragda;Harroch, Sheila
细胞信号传导的基础很大程度上是基于磷酸化状态，磷酸化状态是由蛋白激酶和蛋白磷酸酶活性的平衡所定义的。蛋白酪氨酸激酶在脑发育、脑肿瘤和神经退行性疾病中的作用被广泛研究，然而，蛋白酪氨酸磷酸酶（PTPs）在神经胶质细胞发育中的重要性在一定程度上被忽视了。在这篇综述中，我们总结了PTP在中枢神经系统和大脑不同细胞类型（从干细胞到成熟胶质细胞）发育过程中的表达的最新发现，并强调了这些酶在神经干细胞发育、胶质母细胞瘤和髓鞘形成中的潜在作用。
The cornerstone of cell signaling is largely based on the phosphorylation state that is defined by the equilibrium of the activity of protein kinases and protein phosphatases. The role of protein tyrosine kinases in brain development, brain tumors, and neurodegenerative diseases was studied extensively, yet, the importance of protein tyrosine phosphatases (PTPs) in the development of glial cells was somewhat neglected. In this review, we have summarized recent findings of PTP expression during development of the central nervous system and the different cell types of the brain, from stem cells to mature glial cells, and highlighted the potential role of these enzymes in neuronal stem cell development, glioblastomas, and myelination.