Assessment of Exhaled Breath Condensate pH in Exacerbations of Asthma and Chronic Obstructive Pulmonary Disease A Longitudinal Study
Assessment of Exhaled Breath Condensate pH in Exacerbations of Asthma and Chronic Obstructive Pulmonary Disease A Longitudinal Study
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DOI：
10.1164/rccm.201003-0451oc
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发表时间：
2010-12-15
影响因子：
24.7
通讯作者：
Csiszer, Eszter
中科院分区：
文献类型：
--
作者：
Antus, Balazs;Barta, Imre;Csiszer, Eszter
原理：呼出气冷凝液pH值已被提议作为气道炎症的非侵入性标志物。然而，由于pH测量技术的标准化困难，在以前的研究中获得了不同的pH读数。Objectives：在这项纵向研究中，我们使用非常精确的二氧化碳标准化方法评估了哮喘或慢性阻塞性气道疾病加重患者的冷凝液pH值，该方法否定了这种气体对冷凝液酸度的影响。冷凝液pH值，呼出的一氧化氮分数，肺功能，对20例不吸烟的哮喘患者和21例吸烟和17例非吸烟的哮喘患者进行了血气分析。吸烟的慢性阻塞性气道疾病患者在入院时因疾病急性加重而首次住院，在出院时再次住院治疗后冷凝液pH值也进行了评估，在18吸烟和18不吸烟的健康对照subjects.Measures和主要结果：在哮喘患者中，冷凝液pH值显着降低，在加重时与非吸烟对照组相比，并增加治疗。在慢性阻塞性气道疾病患者中，吸烟者和戒烟者的冷凝液pH值在加重期间保持不变。然而，从吸烟者身上收集的冷凝物比从戒烟者身上收集的冷凝物酸性更强。在吸烟者和非吸烟者健康对照受试者之间观察到类似的差异。冷凝液pH值和呼出的一氧化氮分数或肺功能变量之间没有相关性，在入院或出院时测量。结论：我们的数据表明，哮喘的恶化，但不是慢性阻塞性气道疾病，与呼气冷凝液的酸化。
Rationale: Exhaled breath condensate pH has been proposed as a noninvasive marker of airway inflammation. However, due to standardization difficulties in pH measurement techniques, different pH readings were obtained in previous studies.Objectives: In this longitudinal study we assessed condensate pH in patients with an exacerbation of asthma or chronic obstructive airway disease using the very precise carbon dioxide standardization method that negates the effect of this gas on condensate acidity.Methods: Condensate pH, fractional exhaled nitric oxide, lung function, and blood gases were measured in 20 nonsmoking patients with asthma and 21 smoking and 17 ex-smoking patients with chronic obstructive airway disease first at hospital admission due to an acute exacerbation of the disease and again at discharge after treatment. Condensate pH was also assessed in 18 smoking and 18 nonsmoking healthy control subjects.Measurements and Main Results: In patients with asthma, condensate pH was significantly decreased at the time of exacerbation compared with nonsmoking control subjects and increased with treatment. In patients with chronic obstructive airway disease, condensate pH remained unchanged during exacerbation, both in smokers and ex-smokers. Nevertheless, condensates collected from smokers were more acidic than those of ex-smokers. A similar difference was observed between smoker and nonsmoker healthy control subjects. No correlations were found between condensate pH and fractional exhaled nitric oxide or lung function variables measured either at admission or discharge.Conclusions: Our data suggest that exacerbation of asthma, but not chronic obstructive airway disease, is associated with acidification of breath condensate.