(+)-Alpha-viniferin, a stilbene trimer from Caragana chamlague, inhibits acetylcholinesterase.
(+)-Alpha-viniferin, a stilbene trimer from Caragana chamlague, inhibits acetylcholinesterase.
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DOI：
10.1248/bpb.25.125
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发表时间：
2002
影响因子：
2
通讯作者：
S. Sung;S. Kang;K. Lee;M. Park;Jeong Hun Kim;Jong Hee Park;Young Chul Kim;Jinwoong Kim;Y. Kim
中科院分区：
文献类型：
--
作者：
S. Sung;S. Kang;K. Lee;M. Park;Jeong Hun Kim;Jong Hee Park;Young Chul Kim;Jinwoong Kim;Y. Kim
在筛选天然产物抗乙酰胆碱酯酶（AChE）活性的过程中，我们发现豆科植物锦鸡儿（Caragana chamlague）地下部分的总甲醇提取物对AChE有明显的抑制作用。对总甲醇提取物进行生物活性引导分离鉴定出两种活性二苯乙烯低聚物，(+)- α -乙烯素(1)和kobophenol A(2)。1和2均呈剂量依赖性抑制AChE活性，IC50值分别为2.0和115.8 μ m。1的AChE抑制活性具有特异性、可逆性和非竞争性。
In the course of screening natural products for anti-acetylcholinesterase (AChE) activity, we found that a total methanolic extract of the underground parts of Caragana chamlague (Leguminosae) had significant inhibition towards AChE. Bioactivity-guided fractionation of the total methanolic extract resulted in the isolation and identification of two active stilbene oligomers, (+)-alpha-viniferin (1) and kobophenol A (2). Both 1 and 2 inhibited AChE activity in a dose-dependent manner, and the IC50 values of 1 and 2 were 2.0 and 115.8 microM, respectively. The AChE inhibitory activity of 1 was specific, reversible and noncompetitive.