Functional regional distribution of histamine receptors in the rat hippocampus: modulation of learning of an active avoidance response
Functional regional distribution of histamine receptors in the rat hippocampus: modulation of learning of an active avoidance response
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DOI：
10.1007/s007020100003
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发表时间：
2001
影响因子：
3.3
通讯作者：
E. O. Alvarez;A. M. Banzan-
中科院分区：
文献类型：
--
作者：
E. O. Alvarez;A. M. Banzan-
研究了海马结构中控制主动回避反应学习行为表现的组胺敏感部位的可能功能区域分布。将显微注射套管立体定向植入成年雄性大鼠海马的三个不同区域：腹侧、背后和背前海马。将不同组的大鼠微量注射到这些亚区域中，注射生理盐水、9、45或90 nmol组胺。五分钟后，所有组都接受了对超声波音调的条件反应的学习，警告动物的脚受到电击。为了控制动物学习任务，需要进行三个阶段的8次试验。结果表明，海马腹侧区微量注射组胺能显著抑制逃避潜伏期的自然缩短，降低学习效率。组胺给药到背侧后海马在延长潜伏期和损害学习方面略有效果，而注射到背侧前海马区则没有效果。结果进一步支持腹侧海马组胺敏感神经元调节大鼠记忆和学习机制的观点。此外，有证据表明，组胺敏感神经元的区域分布控制学习的回避反应沿着大鼠海马的隔颞轴。
The possible functional regional distribution of the histamine sensitive sites controlling the behavioral performance of learning of an active avoidance response in the hippocampal structure was studied. Adult male rats were stereotaxically implanted with microinjection cannula into three different regions of the hippocampus: the ventral, the dorsal posterior and the dorsal anterior hippocampus. Different groups of rats were microinjected into these subregions with either saline, 9, 45 or 90 nmol of histamine. Five min later all groups were subjected to learning of a conditioned response to an ultrasonic tone warning an electric shock to the feet of the animals. Three sessions of 8 trials were necessary in order to control animals learn the task. Results show that histamine microinjections into the ventral hippocampus were able to significantly inhibit the natural decrease of the latency to escape during trials, impairing the efficiency of learning. Histamine administration into the dorsal posterior hippocampus was slightly effective in prolonging latency and impairing learning, while injections into the dorsal anterior region of the hippocampus had no effect. Results give a further support to the idea that histamine sensitive neurons in the ventral hippocampus are modulating the memory and learning mechanisms in the rat. In addition, evidence has been found suggesting a regional distribution of histamine sensitive neurons controlling learning of avoidance responses along the septo-temporal axis of the rat hippocampus.