DMF as Carbon Source: Rh-Catalyzed alpha-Methylation of Ketones
DMF as Carbon Source: Rh-Catalyzed alpha-Methylation of Ketones
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DMF 作为碳源：Rh 催化酮的 α-甲基化
DOI：
10.1021/ol403040g
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发表时间：
2014
期刊：
影响因子：
5.2
通讯作者：
Xiao Jianliang
中科院分区：
文献类型：
--
作者：
Li Yang;Xue Dong;Lu Wei;Wang Chao;Liu Zhao-Tie;Xiao Jianliang
公开了一种前所未有的Rh催化的酮与N，N-二甲基甲酰胺(DMF)的直接甲基化反应。该反应的底物范围很广，可以容忍芳基酮和烷基酮的各种取代基。机理研究表明，DMF在甲基化过程中提供亚甲基碎片，然后是氢化物。
An unprecedented Rh-catalyzed direct methylation of ketones withN,N-dimethylformamide (DMF) is disclosed. The reaction shows a broad substrate scope, tolerating both aryl and alkyl ketones with various substituents. Mechanistic studies suggest that DMF delivers a methylene fragment followed by a hydride in the methylation process.