Gene therapy in transplantation.
Gene therapy in transplantation.
复制标题
移植中的基因治疗。
DOI：
10.1038/sj.gt.3300981
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Robbins,P
中科院分区：
文献类型：
--
作者：
Giannoukakis,N;Thomson,A;Robbins,P
实体器官和细胞移植的促进依赖于代谢和免疫因素，这些因素可以使用基因转移技术在体外和体内进行操纵。已经开发了能够最佳地将相关基因转移到各种组织和器官的载体。旨在促进移植前组织保存，预防氧化应激和免疫排斥反应的干预措施最近已成为有吸引力的选择，使用病毒和非病毒基因传递载体。对耐受性诱导机制的进一步理解以及促进异种移植已经使得可以利用基因转移技术的各种途径成为可能。
Facilitation of solid organ and cell transplantation depends on metabolic and immunologic factors that can be manipulated ex vivo and in vivo using gene transfer technology. Vectors have been developed which can optimally transfer relevant genes to various tissues and organs. Interventions aimed at promoting tissue preservation before transplantation, prevention of oxidative stress and immunological rejection have recently become attractive options using viral and nonviral gene delivery vehicles. Further understanding of the mechanisms involved in tolerance induction as well as the facilitation of xenogeneic engraftment have made possible a variety of avenues that can be exploited using gene transfer technology.