Fronto-striatal Dysfunction During Reward Processing in Unaffected Siblings of Schizophrenia Patients
Fronto-striatal Dysfunction During Reward Processing in Unaffected Siblings of Schizophrenia Patients
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DOI：
10.1093/schbul/sbu153
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发表时间：
2015-01-01
影响因子：
6.6
通讯作者：
Vink, Matthijs
中科院分区：
文献类型：
--
作者：
de Leeuw, Max;Kahn, Rene S.;Vink, Matthijs
精神分裂症是一种与额纹状体网络功能受损相关的精神疾病，特别是在奖励处理过程中。然而，目前还不清楚这种功能障碍是否与疾病本身有关，或者它是否反映了发展精神分裂症的遗传脆弱性。在这里，我们研究了奖励处理在精神分裂症患者的未受影响的兄弟姐妹使用功能磁共振成像。采用改良的金钱奖励延迟任务，对27名精神分裂症患者和29名健康志愿者的兄弟姐妹在奖励预期和奖励结果期间的脑活动进行了测量。任务表现在网上被操纵，这样所有的受试者都赢得了相同数量的钱。尽管相同的性能，兄弟姐妹表现出减少激活腹侧纹状体，海马，和补充运动区（SMA）在奖励预期相比，控制。同胞腹侧纹状体激活减少与亚临床阴性症状相关。在奖励的结果，兄弟姐妹表现出增加激活腹侧纹状体和眶额皮质相比，控制。我们发现腹侧纹状体在奖励预期过程中的活动减少，而在接受奖励过程中该区域的活动增加，这可能表明兄弟姐妹的线索处理受损。这与多巴胺功能障碍的概念是一致的，通常与精神分裂症有关。由于未受影响的兄弟姐妹与患病亲属平均共享50%的基因，这些缺陷可能与精神分裂症的遗传易感性有关。
Schizophrenia is a psychiatric disorder that is associated with impaired functioning of the fronto-striatal network, in particular during reward processing. However, it is unclear whether this dysfunction is related to the illness itself or whether it reflects a genetic vulnerability to develop schizophrenia. Here, we examined reward processing in unaffected siblings of schizophrenia patients using functional magnetic resonance imaging. Brain activity was measured during reward anticipation and reward outcome in 27 unaffected siblings of schizophrenia patients and 29 healthy volunteers using a modified monetary incentive delay task. Task performance was manipulated online so that all subjects won the same amount of money. Despite equal performance, siblings showed reduced activation in the ventral striatum, insula, and supplementary motor area (SMA) during reward anticipation compared to controls. Decreased ventral striatal activation in siblings was correlated with sub-clinical negative symptoms. During the outcome of reward, siblings showed increased activation in the ventral striatum and orbitofrontal cortex compared to controls. Our finding of decreased activity in the ventral striatum during reward anticipation and increased activity in this region during receiving reward may indicate impaired cue processing in siblings. This is consistent with the notion of dopamine dysfunction typically associated with schizophrenia. Since unaffected siblings share on average 50% of their genes with their ill relatives, these deficits may be related to the genetic vulnerability for schizophrenia.