Differential requirements for survival and proliferation of CD8 naive or memory T cells
Differential requirements for survival and proliferation of CD8 naive or memory T cells
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DOI：
10.1126/science.276.5321.2057
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发表时间：
1997-06-27
期刊：
影响因子：
56.9
通讯作者：
Rocha, B
中科院分区：
文献类型：
--
作者：
Tanchot, C;Lemonnier, FA;Rocha, B
通过比较携带针对HY抗原的T细胞受体（TCR）的单克隆初始和记忆性CD8（+）T细胞，确定了CD8 T细胞记忆所需的分子相互作用。初始T细胞仅需要正确的主要组织相容性复合体（MHC）I类限制性分子就能存活；要扩增则还需要抗原。相比之下，记忆细胞的存活不需要限制性MHC等位基因，而仅需要非特异性的I类分子；其扩增需要正确的I类分子，但不需要抗原。因此，CD8 T细胞记忆的维持仍然需要TCR - MHC I类分子相互作用，但记忆T细胞可能具有更低的功能激活阈值，这有利于二次应答。
The requisite molecular interactions for CD8 T cell memory were determined by comparison of monoclonal naive and memory CD8(+) T cells bearing the T cell receptor (TCR) for the HY antigen. Naive T cells required only the right major histocompatibility complex (MHC) class I-restricting molecule to survive; to expand, they also needed antigen. In contrast, for survival, memory cells did not require the restricting MHC allele, but needed only a nonspecific class I; for expansion the correct class I, but not antigen, was required. Thus, maintenance of CD8 T cell memory still required TCR-MHC class I interactions, but memory T cells may have a lower functional activation threshold that facilitates secondary responses.