Synovial proliferation differentially affects hypoxia in the joint cavities of rheumatoid arthritis and osteoarthritis patients
Synovial proliferation differentially affects hypoxia in the joint cavities of rheumatoid arthritis and osteoarthritis patients
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DOI：
10.1007/s10067-007-0605-2
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发表时间：
2007-12-01
影响因子：
3.4
通讯作者：
Yang, Hyung-In
中科院分区：
文献类型：
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作者：
Lee, Yeon-Ah;Kim, Jung Yeon;Yang, Hyung-In
本研究旨在探讨滑膜增生（SP）是否对类风湿性关节炎（RA）和骨关节炎（OA）患者关节腔内缺氧有不同的影响。30例RA和42例OA患者接受滑膜炎评估分为两组的基础上存在或不存在的SP，所揭示的肌肉骨骼超声检查。分析膝关节滑液（SF）的白细胞介素（IL）-8，pO（2）和白色血细胞计数，并分析血液样本的红细胞沉降率（ESR）。在SF氧分压（SF pO（2））或IL-8水平方面，在有和没有SP的OA患者之间没有发现差异，而RA患者膝关节的SF pO（2）水平显著低于有SP的OA患者，RA患者关节中的IL-8水平高于OA患者。RA和SP患者SF和组织中浸润的免疫细胞计数明显高于OA和SP患者。在OA患者中，ESRs与SP无相关性，但与RA患者SF pO（2）水平呈负相关。我们的结论是，超声检测SP在OA患者不产生更多的缺氧SF比发现在OA患者没有SP。从RA患者与SP的SF缺氧，这表明SP可能有不同的影响RA和OA患者的关节腔缺氧。
This study was performed to investigate whether synovial proliferation (SP) differentially affects hypoxia in the joint cavities of rheumatoid arthritis (RA) and osteoarthritis (OA) patients. Thirty RA and 42 OA patients who underwent synovitis assessment were classified into two groups based on the presence or absence of SP, as revealed by musculoskeletal ultrasonography. Synovial fluids (SFs) from the knee joints were analyzed for interleukin (IL)-8, pO(2), and white blood cell counts and blood samples were analyzed for erythrocyte sedimentation rate (ESR). No difference was found between the OA patients with and without SP in terms of SF oxygen tension (SF pO(2)) or IL-8 level, whereas the RA patients had significantly lower SF pO(2) levels in their knee joints than did the OA patients with SP, and the RA patients had higher levels of IL-8 in their joints than did the OA patients. The counts of infiltrated immune cells in the SF and tissues were much higher for patients with RA and SP than for those with OA and SP. The ESRs were not found to be correlated with SP in OA patients but were negatively correlated with SF pO(2) levels in RA patients. We conclude that ultrasonographically detected SP in OA patients does not generate a more hypoxic SF than that found in OA patients without SP. The SFs from RA patients with SP are hypoxic, which indicates that SP may have different impacts on hypoxia in the joint cavities of RA and OA patients.