The role of Hippo-YAP signaling in squamous cell carcinomas.
The role of Hippo-YAP signaling in squamous cell carcinomas.
复制标题
Hippo-YAP信号在鳞状细胞癌中的作用。
DOI：
10.1111/cas.14725
复制
发表时间：
2021-01
期刊：
影响因子：
5.7
通讯作者：
Suzuki A
中科院分区：
文献类型：
--
作者：
Maehama T;Nishio M;Otani J;Mak TW;Suzuki A
Hippo雅普通路调节哺乳动物的器官大小、组织稳态和肿瘤发生。响应于细胞密度、外部机械压力和/或其他刺激，Hippo核心复合物控制YAP 1/TAZ蛋白向细胞核的移位，从而调节细胞生长。YAP 1/TAZ的异常上调或核定位发生在许多人类恶性肿瘤中，并促进其形成、进展和转移。一个关键的例子是鳞状细胞癌（SCC）的发生。许多危险因素和与各种组织中SCC发展相关的关键信号加速了YAP 1/TAZ的积累，并且具有组成性激活的YAP 1/TAZ的小鼠在这些组织中显示出立即原位癌（CIS）形成。由于CIS发病是如此之快，在这些突变体中，我们建议，许多SCC启动和进展时，YAP 1活性是持续的，并超过一定的致癌阈值。本文就YAP 1/TAZ在几种SCC中的作用作一综述。我们还讨论了针对异常的YAP 1/TAZ激活是否可能是SCC治疗的一个有前途的策略。我们总结了YAP 1/TAZ在几种类型的SCC中的作用的最新研究结果，提出当YAP 1活性持续并超过一定的致癌阈值时，许多SCC开始并进展。
The Hippo‐YAP pathway regulates organ size, tissue homeostasis, and tumorigenesis in mammals. In response to cell density, external mechanical pressure, and/or other stimuli, the Hippo core complex controls the translocation of YAP1/TAZ proteins to the nucleus and thereby regulates cell growth. Abnormal upregulation or nuclear localization of YAP1/TAZ occurs in many human malignancies and promotes their formation, progression, and metastasis. A key example is squamous cell carcinoma (SCC) genesis. Many risk factors and crucial signals associated with SCC development in various tissues accelerate YAP1/TAZ accumulation, and mice possessing constitutively activated YAP1/TAZ show immediate carcinoma in situ (CIS) formation in these tissues. Because CIS onset is so rapid in these mutants, we propose that many SCCs initiate and progress when YAP1 activity is sustained and exceeds a certain oncogenic threshold. In this review, we summarize the latest findings on the roles of YAP1/TAZ in several types of SCCs. We also discuss whether targeting aberrant YAP1/TAZ activation might be a promising strategy for SCC treatment. We summarize the latest findings on the roles of YAP1/TAZ in several types of SCCs, proposing that many SCCs initiate and progress when YAP1 activity is sustained and exceeds a certain oncogenic threshold.
登录
查看更多内容
影响因子：
11.4
作者：
Lau, Allison N.;Curtis, Stephen J.;Kim, Carla F.
通讯作者：
Kim, Carla F.
影响因子：
4.8
作者：
Garcia-Escudero, Ramon;Segrelles, Carmen;Lorz, Corina
通讯作者：
Lorz, Corina
影响因子：
15.9
作者：
Caulin, Carlos;Nguyen, Thao;Roop, Dennis R.
通讯作者：
Roop, Dennis R.
高危人乳头瘤病毒 E7 对 PTPN14 的降解限制了角质形成细胞的分化，并促进了 HPV 介导的肿瘤发生
DOI：
10.1073/pnas.1819534116
发表时间：
2019-04-02
影响因子：
11.1
作者：
Hatterschide, Joshua;Bohidar, Amelia E.;White, Elizabeth A.
通讯作者：
White, Elizabeth A.
影响因子：
64.8
作者：
Cancer Genome Atlas Research Network;Albert Einstein College of Medicine;Analytical Biological Services;Barretos Cancer Hospital;Baylor College of Medicine;Beckman Research Institute of City of Hope;Buck Institute for Research on Aging;Canada's Michael Smith Genome Sciences Centre;Harvard Medical School;Helen F. Graham Cancer Center &Research Institute at Christiana Care Health Services;HudsonAlpha Institute for Biotechnology;ILSbio, LLC;Indiana University School of Medicine;Institute of Human Virology;Institute for Systems Biology;International Genomics Consortium;Leidos Biomedical;Massachusetts General Hospital;McDonnell Genome Institute at Washington University;Medical College of Wisconsin;Medical University of South Carolina;Memorial Sloan Kettering Cancer Center;Montefiore Medical Center;NantOmics;National Cancer Institute;National Hospital, Abuja, Nigeria;National Human Genome Research Institute;National Institute of Environmental Health Sciences;National Institute on Deafness &Other Communication Disorders;Ontario Tumour Bank, London Health Sciences Centre;Ontario Tumour Bank, Ontario Institute for Cancer Research;Ontario Tumour Bank, The Ottawa Hospital;Oregon Health &Science University;Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center;SRA International;St Joseph's Candler Health System;Eli &Edythe L. Broad Institute of Massachusetts Institute of Technology &Harvard University;Research Institute at Nationwide Children's Hospital;Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University;University of Bergen;University of Texas MD Anderson Cancer Center;University of Abuja Teaching Hospital;University of Alabama at Birmingham;University of California, Irvine;University of California Santa Cruz;University of Kansas Medical Center;University of Lausanne;University of New Mexico Health Sciences Center;University of North Carolina at Chapel Hill;University of Oklahoma Health Sciences Center;University of Pittsburgh;University of São Paulo, Ribeir ão Preto Medical School;University of Southern California;University of Washington;University of Wisconsin School of Medicine &Public Health;Van Andel Research Institute;Washington University in St Louis
通讯作者：
Washington University in St Louis