Central kynurenine pathway shift with age in women
Central kynurenine pathway shift with age in women
复制标题
女性中犬尿氨酸中枢代谢途径随年龄的变化
DOI：
10.1111/jnc.13496
复制
发表时间：
2016-03-01
影响因子：
4.7
通讯作者：
Grant, Ross
中科院分区：
文献类型：
--
作者：
de Bie, Josien;Guest, Jade;Grant, Ross
年龄被认为是大多数神经退行性疾病发展的主要风险因素。犬尿氨酸途径是色氨酸的主要代谢途径，在大多数神经退行性疾病中发生改变。在这项研究中，我们分析了来自49名健康女性的CSF样本，年龄范围很广（0-90岁），用于犬尿氨酸途径代谢物和炎症标志物新蝶呤。我们的研究结果表明，女性的色氨酸代谢随着年龄的增长而增加，并明显转向神经毒素喹啉酸。我们还观察到随着年龄的增长，炎症标记物新蝶呤的中枢水平增加，新蝶呤和犬尿氨酸途径激活之间呈正相关。我们的结论是，在犬尿氨酸通路中发生的变化，作为正常老化的结果是机械相关的炎症信号的增加，并有一些解释的潜力与年龄相关的退行性疾病的中枢神经系统。老龄化和（预防性）治疗中的健康管理将很好地寻找犬尿氨酸途径，以寻找潜在的新解决方案。
Age is considered a dominant risk factor in the development of most neurodegenerative disorders. The kynurenine pathway, a major metabolic pathway of tryptophan is altered in the majority of neurodegenerative disorders. In this study, we have analysed CSF samples from 49 healthy women across a wide age range (0-90) for kynurenine pathway metabolites and the inflammatory marker neopterin. Our results show central tryptophan metabolism is increased with age in women, with an apparent shift towards the neurotoxin quinolinic acid. We also observed an increase in central levels of the inflammatory marker neopterin with age and a positive correlation between neopterin and kynurenine pathway activation. We conclude that, the changes that occur in the kynurenine pathway as a result of normal ageing are mechanistically linked to increased inflammatory signalling and have some explanatory potential with regard to age-associated degenerative diseases in the CNS. Management of health in ageing and (preventative) treatment would do well to look to the kynurenine pathway for potentially novel solutions.