Curcumin Delays Retinal Degeneration by Regulating Microglia Activation in the Retina of rd1 Mice
Curcumin Delays Retinal Degeneration by Regulating Microglia Activation in the Retina of rd1 Mice
复制标题
姜黄素通过调节 rd1 小鼠视网膜小胶质细胞的激活来延缓视网膜变性
DOI：
10.1159/000485085
复制
发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Xu H
中科院分区：
文献类型：
--
作者：
Wang Y;Yin Z;Gao L;Sun D;Hu X;Xue L;Dai J;Zeng Y;Chen S;Pan B;Chen M;Xie J;Xu H
背景/目标：视网膜色素变性（RP）的特征在于光感受器的变性，并且目前对于这种疾病没有有效的治疗方法。然而，姜黄素在RP大鼠和猪模型中显示出神经保护功效，因此可能在这种疾病中具有神经保护作用。研究方法：采用免疫荧光染色、视网膜电图记录和行为学测试分析姜黄素对视网膜变性1（rd 1）小鼠的作用及其机制。结果如下：在生后第14天，姜黄素处理的rd 1小鼠视网膜中凋亡细胞的数量显著减少，视觉功能得到改善。姜黄素可抑制视网膜小胶质细胞的活化、趋化因子和基质金属蛋白酶的分泌。在BV 2小胶质细胞和视网膜衍生的661 W细胞的共培养物中也观察到这些效应。结论：姜黄素通过抑制rd 1小鼠视网膜小胶质细胞的活化延缓视网膜变性。因此，它可能是一种有效的治疗神经退行性疾病，如RP。
Background/Aims: Retinitis pigmentosa (RP) is characterized by degeneration of photoreceptors, and there are currently no effective treatments for this disease. However, curcumin has shown neuroprotectant efficacy in a RP rat and swine model, and thus, may have neuroprotective effects in this disease. Methods: Immunofluorescence staining, electroretinogram recordings, and behavioral tests were used to analyze the effects of curcumin and the underlying mechanism in retinal degeneration 1 (rd1) mice. Results: The number of apoptotic cells in the retina of rd1 mice at postnatal day 14 significantly decreased with curcumin treatment and visual function was improved. The activation of microglia and secretion of chemokines and matrix metalloproteinases in the retina were inhibited by curcumin. These effects were also observed in a co-culture of BV2 microglial cells and retina-derived 661W cells. Conclusions: Curcumin delayed retinal degeneration by suppressing microglia activation in the retina of rd1 mice. Thus, it may be an effective treatment for neurodegenerative disorders such as RP.
登录
查看更多内容
姜黄素类似物 1, 5-bis (2-三氟甲基苯基)-1, 4-pentadien-3-one 表现出增强的 Nrf2 激活能力和针对丙烯醛诱导的 ARPE-19 细胞毒性的保护能力。
影响因子：
3.8
作者：
Li, Yuan;Zou, Xuan;Liu, Jiankang
通讯作者：
Liu, Jiankang
影响因子：
4.4
作者：
Clermont A;Murugesan N;Zhou Q;Kita T;Robson PA;Rushbrooke LJ;Evans DM;Aiello LP;Feener EP
通讯作者：
Feener EP
可生物降解的胶束增强姜黄素的体外和体内抗神经胶质瘤活性
影响因子：
8
作者：
Zheng S;Gao X;Liu X;Yu T;Zheng T;Wang Y;You C
通讯作者：
You C
影响因子：
3.7
作者：
Vasireddy V;Chavali VR;Joseph VT;Kadam R;Lin JH;Jamison JA;Kompella UB;Reddy GB;Ayyagari R
通讯作者：
Ayyagari R
影响因子：
4.3
作者：
Jakobsson, Joel;Bjerke, Maria;Landen, Mikael
通讯作者：
Landen, Mikael