Unexplained rising carcinoembryonic antigen (CEA) in the postoperative surveillance of colorectal cancer: the utility of positron emission tomography (PET)
Unexplained rising carcinoembryonic antigen (CEA) in the postoperative surveillance of colorectal cancer: the utility of positron emission tomography (PET)
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DOI：
10.1016/s0959-8049(01)00049-1
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发表时间：
2001-05-01
影响因子：
8.4
通讯作者：
Mortelmans, L
中科院分区：
文献类型：
--
作者：
Flamen, P;Hoekstra, OS;Mortelmans, L
该研究的目的是评估与[F-18] - 氟脱氧葡萄糖（FDG-PET）生病患者使用正电子发射断层扫描，在结直肠癌的术后监测中，患有无法解释的carcinoembryonic抗原（CEA）。回顾性地选择了50例CEA水平升高和完全正常（n = 31）或模棱两可（n = 19）常规诊断检查（CDW）的患者。所有PET图像均已充分了解CDW。黄金标准包括组织学或超过1年的临床随访。 43例患者的56例病变中建立了复发性疾病。在基于患者的分析中，FDG-PET的敏感性为34/43（79％），阳性预测值为34/38（89％）。在14/50例患者中（28％）。 FDG-PET的发现导致具有治愈性的手术切除。在基于病变的分析中，FDG-PET检测到42/56病变（灵敏度：75％），阳性预测值为79％（42/53）。这些结果表明，FDG-PET可以对CEA水平无法解释的升高的患者对患者管理产生明显影响。 （c）2001 Elsevier Science Ltd.保留所有权利。
The aim of the study was to evaluate the use of positron emission tomography with [F-18]-fluorodeoxyglucose (FDG-PET) ill patients with unexplained rising carcinoembryonic antigen (CEA) in the postoperative surveillance of colorectal cancer. 50 consecutive patients with elevated CEA levels and a completely normal (n = 31) or equivocal (n = 19) conventional diagnostic work-up (CDW) were retrospectively selected. All PET images were reviewed with full knowledge of the CDW. The gold standard consisted of histology, or clinical follow-up of more than 1 year. Recurrent disease was established in 56 lesions in 43 patients. On a patient-based analysis, the sensitivity of FDG-PET was 34/43 (79%), and the positive predictive value 34/38 (89%). In 14/50 patients (28%). the FDG-PET findings led to a surgical resection with curative intent. On a lesion-based analysis, FDG-PET detected 42/56 lesions (sensitivity: 75%), the positive predictive value was 79% (42/53). These results demonstrate that FDG-PET can have a clear impact on patient management in patients with an unexplained elevation in CEA levels. (C) 2001 Elsevier Science Ltd. All rights reserved.