Assessment of quality of life in patients with uncontrolled vs. controlled acromegaly using the Acromegaly Quality of Life Questionnaire (AcroQoL)
Assessment of quality of life in patients with uncontrolled vs. controlled acromegaly using the Acromegaly Quality of Life Questionnaire (AcroQoL)
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DOI：
10.1111/j.1365-2265.2005.02307.x
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发表时间：
2005-07-01
影响因子：
3.2
通讯作者：
Christ, ER
中科院分区：
文献类型：
--
作者：
Trepp, R;Everts, R;Christ, ER
目的肢端肥大症是一种严重影响患者生活质量的慢性疾病。肢端肥大症疾病产生的生活质量问卷（AcroQoL）最近被开发出来。我们的目的是确认AcroQoL问卷的信度、构建效度和疾病特异性。其次，我们研究了缓解状态对肢端肥大症患者健康相关生活质量（HRQoL）的影响。采用前瞻性、横断面设计，33例肢端肥大症患者和22例接受稳定替代治疗的激素无活性垂体腺瘤患者完成了德文版本的AcroQoL问卷。测量和结果Cronbach α分析显示，肢端肥大症患者的总分、各量表和亚量表具有较高的信度（α值范围为0.83 ~ 0.93，项目-总相关系数为0.41 ~ 0.84）。无激素垂体腺瘤患者的可靠性较低（α值范围为0.17至0.75）。对肢端肥大症患者的探索性因素分析表明，两因素解决方案的项目分布与原始西班牙问卷的量表基本匹配。多元回归分析显示，与缓解或不一致缓解状态的肢端肥大症患者相比，持续肢端肥大症患者的总得分、不同量表和亚量表（表明HRQoL较差）显著降低。一致地，igf - 1是问卷不同分数的独立负向预测因子。结论AcroQoL问卷是评估肢端肥大症患者健康相关生活质量的可靠、有效和疾病特异性的工具。生物化学控制的肢端肥大症患者的HRQoL明显低于缓解或不一致缓解状态的肢端肥大症患者。
Objective Acromegaly is a chronic disease with an important impact on quality of life. An acromegaly disease-generated quality of life questionnaire (AcroQoL) has recently been developed. We aimed to confirm reliability, construct validity and disease-specificity of the AcroQoL questionnaire. Second, we investigated the effect of remission status on health-related quality of life (HRQoL) in patients with acromegaly.Design and patients Using a prospective, cross-sectional design, 33 patients with treated acromegaly and 22 patients with treated hormone-inactive pituitary adenoma under stable replacement therapy completed the German version of the AcroQoL questionnaire.Measurements and results Cronbach's alpha analysis showed high reliability of the total score and the different scales and subscales in patients with acromegaly (alpha ranging from 0.83 to 0.93, item-total correlation 0.41-0.84). Patients with hormone-inactive pituitary adenoma showed lower reliability (alpha ranging from 0.17 to 0.75). Exploratory factor analysis in patients with acromegaly suggested a two-factorial solution with item distribution largely matching the scaling of the original Spanish questionnaire. Multiple regression analysis revealed significantly lower results of the total score and the different scales and subscales (indicating worse HRQoL) in patients with persistent acromegalic activity compared to patients with acromegaly in remission or discordant remission status. Consistently, IGF-I was an independent negative predictor of the different scores of the questionnaire.Conclusions The AcroQoL questionnaire represents a reliable, construct valid and disease-specific tool for assessing health-related quality of life in patients with acromegaly. Patients with biochemically uncontrolled acromegaly showed significantly lower HRQoL than patients with acromegaly in remission or discordant remission status.