Simulated propagation of cardiac action potentials.
Simulated propagation of cardiac action potentials.
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DOI：
10.1016/s0006-3495(80)85068-5
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发表时间：
1980-09
影响因子：
3.4
通讯作者：
G. H. Sharp;R. W. Joyner
中科院分区：
文献类型：
--
作者：
G. H. Sharp;R. W. Joyner
我们已经使用数值方法求解电缆方程，结合先前发表的数学模型的心室和浦肯野细胞的膜特性，模拟心脏动作电位的传播沿着一维链。两种类型的不均匀性进行了模拟，并与实验观察到的干扰心脏动作电位传播的结果进行了比较。在膜模型中的变化的链的区域被引入到模拟区域的兴奋性降低。还研究了细胞间偶联的区域变化。结果说明，并有助于解释干扰传播已报告发生在兴奋性降低的地区，不断变化的动作电位持续时间的地区，或地区与不断变化的细胞间耦合。在所有这些地区看到的传播干扰进行了讨论，在不断变化的电力负载施加在传播脉冲。
We have used numerical methods for solving cable equations, combined with previously published mathematical models for the membrane properties of ventricular and Purkinje cells, to simulate the propagation of cardiac action potentials along a unidimensional strand. Two types of inhomogeneities have been simulated and the results compared with experimentally observed disturbances in cardiac action potential propagation. Changes in the membrane model for regions of the strand were introduced to simulate regions of decreased excitability. Regional changes in the intercellular coupling were also studied. The results illustrate and help to explain the disturbances in propagation which have been reported to occur at regions of decreased excitability, regions with changing action potential duration, or regions with changing intercellular coupling. The propagational disturbances seen at all of these regions are discussed in terms of the changing electrical load imposed upon the propagating impulse.