Significance of Histiocytes on Otherwise-Normal Cervical Smears from Postmenopausal Women
Significance of Histiocytes on Otherwise-Normal Cervical Smears from Postmenopausal Women
复制标题
组织细胞对绝经后妇女正常宫颈涂片的意义
DOI：
10.1159/000326493
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发表时间：
2003
期刊：
影响因子：
1.8
通讯作者：
F. Abdul
中科院分区：
文献类型：
--
作者：
P. Wen;C. Abramovich;Nancy Wang;Natalie Knop;Sallie Mansbacher;F. Abdul
目的
探讨绝经后妇女正常宫颈涂片中组织细胞的意义及其与子宫内膜病理的关系。
研究设计
组织细胞分为三种类型。从细胞学和手术报告中获得临床病史。
结果
在108例宫颈涂片中，13例有大的泡沫状组织细胞（A型），88例有类似于浅表子宫内膜间质细胞的组织细胞（B型），7例有单独或与炎性或多核细胞相关的肥大组织细胞（C型）。13例患者（12.0%）确定了子宫内膜病理学：4/13例为A型组织细胞（2例子宫内膜腺癌，2例子宫内膜息肉），8/88例为B型组织细胞（8例子宫内膜息肉），1/7例为C型组织细胞（子宫内膜息肉）。在70例除组织细胞外无临床指征的子宫内膜取样患者中，4例显示子宫内膜病理（均为子宫内膜息肉）。相比之下，9/38例有子宫内膜取样临床指征的患者发现了子宫内膜病理。在13例子宫内膜病理的患者中，9例有明显的临床病史（敏感性为69.2%），4例以组织细胞作为子宫内膜活检的唯一指征（敏感性为30.8%）。
结论
有意义的临床病史更能预测子宫内膜病理，其重要性超过组织细胞作为子宫内膜活检指征的意义。
OBJECTIVE
To evaluate the significance of histiocytes on normal cervical smears from postmenopausal women and correlate them with endometrial pathology.
STUDY DESIGN
Histiocytes were classified into three types. The clinical history was obtained from cytologic and surgical reports.
RESULTS
Among 108 cervical smears, 13 had large, foamy histiocytes (type A), 88 had histiocytes resembling superficial endometrial stromal cells (type B), and 7 had variably sized histiocytes alone or in association with inflammatory or multinucleated cells (type C). Endometrial pathology was identified in 13 patients (12.0%): 4/13 with type A histiocytes (2 endometrial adenocarcinomas, 2 endometrial polyps), 8/88 with type B histiocytes (8 endometrial polyps) and 1/7 with type C histiocytes (endometrial polyp). Among 70 patients with no clinical indications for endometrial sampling except for the presence of histiocytes, 4 demonstrated endometrial pathology (all endometrial polyps). In contrast, endometrial pathology was identified in 9/38 with clinical indications for endometrial sampling. Among the 13 patients with endometrial pathology, 9 had a significant clinical history (sensitivity of 69.2%), and 4 had histiocytes as the only indication for endometrial biopsy (sensitivity of 30.8%).
CONCLUSION
A significant clinical history is more predictive of endometrial pathology and outweighs the significance of histiocytes as an indication for endometrial biopsy.