A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
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DOI：
10.1038/382319a0
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发表时间：
1996-07-25
期刊：
影响因子：
64.8
通讯作者：
Nakatani, Y
中科院分区：
文献类型：
--
作者：
Yang, XJ;Ogryzko, VV;Nakatani, Y
腺病毒癌蛋白 E1A 通过与 p300/CBP 和视网膜母细胞瘤基因家族的产物结合，诱导细胞周期的进展。一种具有内在组蛋白乙酰化酶活性的新细胞 p300/CBP 相关因子 (P/CAF) 已被发现，可与 E1A 竞争。 HeLa 细胞中 P/CAF 的外源表达抑制细胞周期进程并抵消 E1A 的有丝分裂活性。 E1A 扰乱 p300/CBP 及其相关组蛋白乙酰化酶之间的正常细胞相互作用。
The adenoviral oncoprotein E1A induces progression through the cell cycle by binding to the products of the p300/CBP and retinoblastoma gene families. A new cellular p300/CBP-associated factor (P/CAF) having intrinsic histone acetylase activity has been identified that competes with E1A. Exogenous expression of P/CAF in HeLa cells inhibits cell-cycle progression and counteracts the mitogenic activity of E1A. E1A disturbs the normal cellular interaction between p300/CBP and its associated histone acetylase.