Lack of effectiveness of tramadol hydrochloride for the treatment of pain and joint dysfunction in dogs with chronic osteoarthritis
Lack of effectiveness of tramadol hydrochloride for the treatment of pain and joint dysfunction in dogs with chronic osteoarthritis
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DOI：
10.2460/javma.252.4.427
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发表时间：
2018-02-15
影响因子：
1.9
通讯作者：
Berjeski, Amanda K.
中科院分区：
文献类型：
--
作者：
Budsberg, Steven C.;Torres, Bryan T.;Berjeski, Amanda K.
目的：探讨曲马多治疗犬骨关节炎的有效性。方法：采用随机、双盲、安慰剂对照、交叉试验的方法，对40只患有手肘关节或膝关节骨关节炎的犬进行研究。方法：（早上、中午和晚上），持续10天，每次3次相同的治疗（安慰剂;卡洛芬2.2 mg/kg [1 mg/lb]，每12 h一次[早晚]，安慰剂在中午给药;或盐酸曲马多5 mg/kg [2.3 mg/lb]，每8 h一次），以随机顺序给药，治疗阶段之间间隔至少7天的洗脱期。测量垂直地面反作用力（垂直冲量[VI]和峰值垂直力[PVF]），并在每个治疗期之前（基线）和结束时分配犬简明疼痛量表（CBPI）评分。进行重复测量ANOVA以比较处理之间和处理内的VI和PVF数据，并使用卡方检验比较CBPI定义的对处理的阳性反应的犬比例。完成研究的是100 TS 35犬。在安慰剂和曲马多治疗组中，未发现VI和PVF较基线的显著变化;然而，卡洛芬治疗组的这些值显著增加。卡洛芬治疗组VI和PVF值较基线的变化显著大于安慰剂或曲马多治疗组。一个显着的改善，从基线CBPI评分与卡洛芬治疗，但不是安慰剂或tramadol treatment.CONCLUSIONS和临床RELEVANCE 10天的治疗与曲马多的管理（5毫克/公斤，PO，q 8小时）提供了没有临床效益的手肘关节或膝关节骨关节炎。
OBJECTIVETo investigate the effectiveness of tramadol for treatment of osteoarthritis in dogs.DESIGNRandomized, blinded, placebo-controlled crossover study.ANIMALS40 dogs with clinical osteoarthritis of the elbow or stifle joint.PROCEDURESDogs orally received 3 times/d (morning, midday, and night) for a 10-day period each of 3 identically appearing treatments (placebo; carprofen at 2.2 mg/kg [1 mg/lb], q 12 h [morning and night], with placebo at midday; or tramadol hydrochloride at 5 mg/kg [2.3 mg/lb], q 8 h) in random order, with treatment sessions separated by a minimum 7-day washout period. Vertical ground reaction forces (vertical impulse [VI] and peak vertical force [PVF]) were measured and Canine Brief Pain Inventory (CBPI) scores assigned prior to (baseline) and at the end of each treatment period. Repeated-measures ANOVA was performed to compare VI and PVF data among and within treatments, and the chi(2) test was used to compare proportions of dogs with a CBPI-defined positive response to treatment.RESULTS35 dogs completed the study. No significant changes from baseline in VI and PVF were identified for placebo and tramadol treatments; however, these values increased significantly with carprofen treatment. Changes from baseline in VI and PVF values were significantly greater with carprofen versus placebo or tramadol treatment. A significant improvement from baseline in CBPI scores was identified with carprofen treatment but not placebo or tramadol treatment.CONCLUSIONS AND CLINICAL RELEVANCE10 days of treatment with tramadol as administered (5 mg/kg, PO, q 8 h) provided no clinical benefit for dogs with osteoarthritis of the elbow or stifle joint.