Stromal vascularization prevents corneal ulceration.
Stromal vascularization prevents corneal ulceration.
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基质血管化可防止角膜溃疡。
DOI：
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发表时间：
1980
影响因子：
4.4
通讯作者：
J. Gage
中科院分区：
文献类型：
--
作者：
H. Conn;M. Berman;K. Kenyon;R. Langer;J. Gage
用局灶性热诱导溃疡模型进行实验，以测试血管化防止角膜基质溃疡的临床印象。将含有血管增殖酶试剂（肿瘤血管生成因子）的缓释聚合物置于白化病兔的利姆布斯中心2 mm的角膜袋中。这些聚合物引起血管向内生长直至植入物。对照眼接受空聚合物，其引起最小至无血管生长。聚合物被移除，并且每个角膜接受位于聚合物部位中央的局灶性热烧伤。所有对照角膜溃疡：大多数（79%）发展为深层基质或穿孔性溃疡。只有25%的预血管化角膜发生了基质溃疡，没有一个是深溃疡或穿孔性溃疡。热烧伤后，两组中的血管以相同的线性速率向烧伤区域生长。烧伤时距离最近的血管与烧伤面积的距离与基质溃疡的最大深度有直接关系。因此，预防或减轻严重程度的基质溃疡与烧伤区域血管的早期出现有关。
Experiments were performed with a model of focal, thermal-induced ulceration to test the clinical impression that vascularization prevents ulceration of the corneal stroma. Slow-release polymers containing a vasoproliferase agent (tumor angiogenesis factor) were placed in corneal pockets 2 mm central to the limbus of albino rabbits. These polymers elicited blood vessel ingrowth up to the implant. Control eyes received empty polymers which caused minimal to no vessel growth. Polymers were removed, and each cornea received a focal, thermal burn placed just central to the polymer site. All control corneas ulcerated: most (79%) developed deep stromal or perforating ulcers. Only 25% of prevascularized corneas developed stromal ulcers, and none was deep or perforating. After thermal burns, vessels in both groups grew at the same linear rate toward the burned area. There was a direct relationship between the distance separating the nearest blood vessel and the burned area at the time of burning and the maximum depth of stromal ulceration. Thus prevention of or less severe stromal ulceration is correlated with the earlier presence of vessels in the burned area.