Wavefront correction and high-resolution in vivo OCT imaging with an objective integrated multi-actuator adaptive lens
Wavefront correction and high-resolution in vivo OCT imaging with an objective integrated multi-actuator adaptive lens
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DOI：
10.1364/oe.23.021931
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发表时间：
2015-08-24
期刊：
影响因子：
3.8
通讯作者：
Sarunic, Marinko V.
中科院分区：
文献类型：
--
作者：
Bonora, Stefano;Jian, Yifan;Sarunic, Marinko V.
自适应光学正在迅速改变显微镜和高分辨率眼科成像。常用的自适应元件有液晶空间光调制器和变形镜。我们介绍了一种新型的多致动器自适应透镜，它可以将像差校正到高阶，并且通过简化其与现有系统的集成，有可能增加自适应光学在许多新应用中的传播。我们的方法将自适应透镜与基于图像的优化控制相结合，允许将图像校正到衍射极限，并且相对于现有的最先进的自适应光学系统，减少了硬件复杂性。我们提出的多致动器自适应透镜设计可以校正波前像差到泽尼克多项式表征的4阶。采用Shack-Hartmann波前传感器进行闭环控制，在大视场显微镜下演示了多致动器自适应透镜的性能。多致动器自适应透镜和基于图像的波前无传感器控制也被集成到用于小鼠视网膜结构体内成像的傅里叶域光学相干断层扫描系统的物镜中。实验结果表明，多致动器物镜的插入可以产生任意波前，对像差的校正可以达到衍射极限，并且可以很容易地集成到光学系统中，以提高像差的质量。(C) 2015美国光学学会
Adaptive optics is rapidly transforming microscopy and high-resolution ophthalmic imaging. The adaptive elements commonly used to control optical wavefronts are liquid crystal spatial light modulators and deformable mirrors. We introduce a novel Multi-actuator Adaptive Lens that can correct aberrations to high order, and which has the potential to increase the spread of adaptive optics to many new applications by simplifying its integration with existing systems. Our method combines an adaptive lens with an imaged-based optimization control that allows the correction of images to the diffraction limit, and provides a reduction of hardware complexity with respect to existing state-of-the-art adaptive optics systems. The Multi-actuator Adaptive Lens design that we present can correct wavefront aberrations up to the 4th order of the Zernike polynomial characterization. The performance of the Multi-actuator Adaptive Lens is demonstrated in a wide field microscope, using a Shack-Hartmann wavefront sensor for closed loop control. The Multi-actuator Adaptive Lens and image-based wavefront-sensorless control were also integrated into the objective of a Fourier Domain Optical Coherence Tomography system for in vivo imaging of mouse retinal structures. The experimental results demonstrate that the insertion of the Multi-actuator Objective Lens can generate arbitrary wavefronts to correct aberrations down to the diffraction limit, and can be easily integrated into optical systems to improve the quality of aberrated images. (C) 2015 Optical Society of America