NONINVASIVE LONG-TERM VENTILATORY SUPPORT FOR INDIVIDUALS WITH SPINAL MUSCULAR-ATROPHY AND FUNCTIONAL BULBAR MUSCULATURE
NONINVASIVE LONG-TERM VENTILATORY SUPPORT FOR INDIVIDUALS WITH SPINAL MUSCULAR-ATROPHY AND FUNCTIONAL BULBAR MUSCULATURE
复制标题
DOI：
10.1016/s0003-9993(95)80603-2
复制
发表时间：
1995-03-01
影响因子：
4.3
通讯作者：
WANG, TG
中科院分区：
文献类型：
--
作者：
BACH, JR;WANG, TG
10例脊髓性肌萎缩症（SMA）和慢性通气功能不全患者接受辅助咳嗽技术训练，并通过口腔和/或鼻腔界面接受间歇正压通气（IPPV），平均5.3年（范围= 1至17年）。在此期间，他们的呼吸并发症明显少于引入无创呼吸肌辅助设备之前，尽管10人中有6人每天需要使用呼吸机超过20小时，而无呼吸机呼吸时间（VFBT）少于2小时。除2例非侵入性IPPV使用者外，所有患者的肺活量（vc）均低于预期正常值的13%，但他们可以口头交流并口服营养，所有患者都留在社区。5名患者有工作，4名患者在上学。我们的结论是，无创呼吸肌辅助包括无创IPPV和辅助咳嗽技术是有效的和实用的替代气管切开术的SMA患者呼吸衰竭，但球肌功能正常。
Ten individuals with spinal muscular atrophy (SMA) and chronic ventilatory insufficiency were trained in the use of assisted coughing techniques and received intermittent positive pressure ventilation (IPPV) via oral and/or nasal interfaces for a mean of 5.3 (range = 1 to 17) years. During this time they had significantly fewer respiratory complications than before introduction of noninvasive respiratory muscle aids despite the fact that 6 of the 10 went on to require more than 20 hours per day of ventilator use with less than 2 hours of ventilator-free breathing time (VFBT). All except two noninvasive IPPV users had vital capacities (VCs) less than 13% of predicted normal, They could, however, communicate verbally and take nutrition by mouth, All of the patients remained in the community. Five patients were gainfully employed and four were in school. We conclude that noninvasive respiratory muscle aids including noninvasive IPPV and assisted coughing techniques are effective and practical alternatives to tracheostomy for SMA patients with ventilatory failure but functional bulbar musculature.