Differential antibody isotype expression to the major Paracoccidioides brasiliensis antigen in juvenile and adult form paracoccidioidomycosis
Differential antibody isotype expression to the major Paracoccidioides brasiliensis antigen in juvenile and adult form paracoccidioidomycosis
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DOI：
10.1016/s1286-4579(99)80022-7
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发表时间：
1999-04-01
影响因子：
5.8
通讯作者：
Benard, G
中科院分区：
文献类型：
--
作者：
Baida, H;Biselli, PJC;Benard, G
我们研究了对主要的巴氏副球虫抗原(一种43 kDa的糖蛋白)的抗体反应与两种副球囊真菌病(PCM)临床表现的关系。采用酶联免疫吸附试验检测患者血清中总免疫球蛋白G(Ig G)、Ig G亚型和Ig A抗gp43抗体。青少年PCM患者血清中抗gp43抗体水平显著高于成年型患者(P=0.003)。然而，IgG1亚类水平在两种临床形式之间是相似的。少年型患者较高(P<0.05)。
We investigated the relationship between antibody response to the major Paracoccidioides brasiliensis antigen, a 43-kDa glycoprotein, and the two paracoccidioidomycosis (PCM) clinical presentations, the juvenile and the adult forms. Total immunoglobulin G (IgG), IgG isotypes, and IgA anti-gp43 antibodies were determined by enzyme-linked immunosorbent assay in patients' sera. Juvenile PCM patients had higher (P =.003) IgG anti-gp43 levels than adult form patients. IgG1 subclass levels, however, were comparable between the two clinical forms. Patients with the juvenile form had higher (P