A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis
A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis
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DOI：
10.1038/nature05722
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发表时间：
2007-04-12
期刊：
影响因子：
64.8
通讯作者：
Clarke, Jonathan D. W.
中科院分区：
文献类型：
--
作者：
Tawk, Marcel;Araya, Claudio;Clarke, Jonathan D. W.
细胞极性的发展是胚胎发生过程中组织形态发生的重要先决条件，特别是在上皮细胞的发育过程中(1,2)。此外，定向细胞分裂可以对组织形态发生产生强大影响(3)。在这里，我们发现了一种新的极化细胞分裂模式，它在发育中的斑马鱼神经管中产生一对具有镜像对称极性的神经祖细胞，并对胚胎组织的组织产生巨大的影响。我们发现，在神经杆形成过程中，极性蛋白 Pard3 定位于分裂祖细胞的卵裂沟，然后由两个子细胞镜像对称地遗传。这使得子细胞能够整合到发育中的神经管的相对侧。此外，这些镜像对称分裂具有强大的形态发生影响：当在神经形成过程中被迫发生在异位位置时，它们协调镜像图案形成的发展以及随后异位神经管的产生。
The development of cell polarity is an essential prerequisite for tissue morphogenesis during embryogenesis, particularly in the development of epithelia(1,2). In addition, oriented cell division can have a powerful influence on tissue morphogenesis(3). Here we identify a novel mode of polarized cell division that generates pairs of neural progenitors with mirror-symmetric polarity in the developing zebrafish neural tube and has dramatic consequences for the organization of embryonic tissue. We show that during neural rod formation the polarity protein Pard3 is localized to the cleavage furrow of dividing progenitors, and then mirror-symmetrically inherited by the two daughter cells. This allows the daughter cells to integrate into opposite sides of the developing neural tube. Furthermore, these mirror-symmetric divisions have powerful morphogenetic influence: when forced to occur in ectopic locations during neurulation, they orchestrate the development of mirror-image pattern formation and the consequent generation of ectopic neural tubes.