Curcumin, a polyphenolic antioxidant, attenuates chronic fatigue syndrome in murine water immersion stress model
Curcumin, a polyphenolic antioxidant, attenuates chronic fatigue syndrome in murine water immersion stress model
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DOI：
10.1016/j.imbio.2008.04.003
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发表时间：
2009-01-01
期刊：
影响因子：
2.8
通讯作者：
Chopra, Kanwaljit
中科院分区：
文献类型：
--
作者：
Gupta, Amit;Vij, Garima;Chopra, Kanwaljit
在流行病学案例研究中，慢性疲劳综合症、感染和氧化应激是相互关联的。然而，缺乏证明营养补充剂对慢性疲劳综合症有效性的流行病学主张的科学验证的数据。本研究旨在评估天然多酚姜黄素在免疫诱导疲劳小鼠模型中的作用，其中纯化脂多糖 (LPS) 和流产布鲁氏菌 (BA) 抗原用作免疫原。慢性疲劳综合征的评估以每天10分钟的慢性浸水压力试验为基础，持续19天，以不动时间作为疲劳的标志。用 LPS 或 BA 攻击 19 天的小鼠在第 19 天表现出不动时间和痛觉过敏显着增加，并且血清肿瘤坏死因子-α (TNF-α) 水平显着增加。姜黄素同时治疗可显着减少不动时间以及痛觉过敏。氧化应激和 TNF-α 水平显着减弱。这些发现强烈表明，在免疫激活过程中，氧化应激显着增加，姜黄素可能是治疗慢性疲劳综合症的一个有价值的选择。 (C) 2008 爱思唯尔有限公司。版权所有。
Chronic fatigue syndrome, infection and oxidative stress are interrelated in epidemiological case studies. However, data demonstrating scientific validation of epidemiological claims regarding effectiveness of nutritional supplements for chronic fatigue syndrome are lacking. This study is designed to evaluate the effect of natural polyphenol, curcumin, in a mouse model of immunologically induced fatigue, where purified lipopolysaccharide (LPS) and Brucella abortus (BA) antigens were used as immunogens. The assessment of chronic fatigue syndrome was based on chronic water-immersion stress test for 10 min daily for 19 days and the immobility time was taken as the marker of fatigue. Mice challenged with LPS or BA for 19 days showed significant increase in the immobility time and hyperalgesia on day 19, as well as marked increase in serum tumor necrosis factor-alpha (TNF-alpha) levels. Concurrent treatment with curcumin resulted in significantly decreased immobility time as well as hyperalgesia. There was significant attenuation of oxidative stress as well as TNF-alpha levels. These findings strongly suggest that during immunological activation, there is significant increase in oxidative stress and curcumin can be a valuable option in the treatment of chronic fatigue syndrome. (C) 2008 Elsevier GmbH. All rights reserved.