Comparing the EQ-5D 3L and 5L: measurement properties and association with chronic conditions and multimorbidity in the general population
Comparing the EQ-5D 3L and 5L: measurement properties and association with chronic conditions and multimorbidity in the general population
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DOI：
10.1186/1477-7525-12-74
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发表时间：
2014-05-16
影响因子：
3.6
通讯作者：
Johnson, Jeffrey A.
中科院分区：
文献类型：
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作者：
Agborsangaya, Calypse B.;Lahtinen, Markus;Johnson, Jeffrey A.
背景资料：比较EQ-5D 3L（3L）和EQ-5D 5L（5L）测量特性的研究仅限于样本量较小的特定患者人群。使用一般人群样本，我们比较了3L和5L的测量特性以及与慢性疾病数量的相关性，包括多发性硬化-同时发生两种或多种慢性疾病。方法：数据来自连续两个周期的横断面电话访谈调查，使用3L（2010年周期）和5L（2012年周期），在加拿大阿尔伯塔的成年人（年龄>= 18岁）的一般人群中。测量性能进行了比较，确定其可行性，天花板效应，和歧视的权力（香农指数）为3L和5L。线性回归模型拟合测试之间的关联多morphism和EQ-5D指数score.Results：数据可用于4946（2010年）和4752（2012年）的调查受访者与HRQL的信息。与3L相比，5L显示出更低的天花板效应（32.3%对42.1%）、更高的绝对辨别力（Shannon指数，平均0.79对0.52）和更高的相对辨别力（Shannon均匀度指数，平均0.09对3L的0.06）。尽管存在这些差异，但在3L（β =-0.13，95% CI -0.15; -0.11）和5L（β =-0.12，95% CI -0.13; -0.11）中观察到较低HRQL与较高多变量的相似关系。结论：使用一般人群样本，EQ-5D 5L显示出比EQ-5D 3L更好的测量特性。尽管如此，使用两个版本的EQ-5D，与多项死亡相关的HRQL的临床重要差异的幅度相似。
Background: Studies comparing the measurement properties of EQ-5D 3L (3L) and EQ-5D 5L (5L) are limited to specific patient populations with small sample sizes. Using a general population sample, we compared 3L and 5L in terms of their measurement properties and association with number of chronic conditions, including multimorbidity - the concurrent occurrence of two or more chronic conditions.Methods: Data were available from two consecutive cycles of a cross-sectional telephone interview survey using 3L (2010 cycle) and 5L (2012 cycle), in the general population of adults (age >= 18 years) in Alberta, Canada. Measurement properties were compared by determining their feasibility, ceiling effect, and discriminatory power (Shannon indices) for 3L and 5L. Linear regression models were fitted to test the associations between multimorbidity and EQ-5D index score.Results: Data were available for 4946 (2010) and 4752 (2012) survey respondents with information on HRQL. Compared to 3L, 5L showed lower ceiling effect (32.3% versus 42.1%), higher absolute discriminatory power (Shannon index, mean 0.79 versus 0.52) and higher relative discriminatory power (Shannon Evenness index, mean 0.09 versus 0.06 for 3L). Despite these differences, similar relationships of lower HRQL with greater multimorbidity were observed for the 3L (beta = -0.13, 95% CI -0.15; -0.11) and 5L (beta = -0.12, 95% CI -0.13; -0.11).Conclusions: Using a general population sample, the EQ-5D 5L showed better measurement properties than the EQ-5D 3L. Nonetheless, clinically important differences in HRQL associated with multimorbidity were similar in magnitude using both versions of EQ-5D.