Total tooth loss and prevalent cardiovascular disease in men and women - Possible roles of citrus fruit consumption, vitamin C, and inflammatory and thrombotic variables
Total tooth loss and prevalent cardiovascular disease in men and women - Possible roles of citrus fruit consumption, vitamin C, and inflammatory and thrombotic variables
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DOI：
10.1016/s0895-4356(03)00086-6
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发表时间：
2003-07-01
影响因子：
7.2
通讯作者：
Stephen, K
中科院分区：
文献类型：
--
作者：
Lowe, G;Woodward, M;Stephen, K
背景和意义牙齿缺失与心血管疾病（CVD）有关，但其机制尚不清楚.我们评估了与流行的CVD在男性和女性的总牙齿损失的关联，以及柑橘类水果的消费，血浆维生素C，炎症和血栓形成variables.MethodsWe使用了年龄和性别分层的人口调查，男性和女性年龄在25-74岁，在北格拉斯哥. Results38%的女性和29%的男性缺牙。在两种性别中，牙齿全部脱落与普遍的CVD相关。在调整主要潜在混杂因素（年龄、性别、吸烟和社会阶层）后，无牙颌患者普遍CVD的比值比（95%CI）为1.55（1.13，2.13）。总的牙齿损失也与低柑橘类水果的消费和低血浆维生素C水平，增加血浆C-反应蛋白的男性，并与增加血浆白细胞介素-6，纤维蛋白原，和因子VIII的水平women.ConclusionPrevalent CVD是与总的牙齿损失。可能的机制包括柑橘类水果摄入量低，因此，血浆维生素C水平低，以及易患低度炎症和血栓形成。这可能是谨慎的，以确保足够的维生素C摄入量的人没有牙齿。
Background and ObjectiveTooth loss has been associated with cardiovascular disease (CVD), but the mechanisms are unclear. We evaluated the association of total tooth loss with prevalent CVD in men and women; as well as with citrus fruit consumption, plasma vitamin C, and inflammatory and thrombotic variables.MethodsWe used an age-and sex-stratified population survey, of men and women aged 25–74 years, in North Glasgow.ResultsThirty-eight percent of women and 29% of men were edentulous. Total tooth loss was associated with prevalent CVD in both sexes. After adjustment for major potential confounders (age, sex, smoking, and social class), the odds ratio (95% CI) for prevalent CVD was 1.55 (1.13, 2.13) in the edentulous. Total tooth loss was also associated with low citrus fruit consumption and low plasma vitamin C levels, increased plasma C-reactive protein in men, and with increased plasma interleukin-6, fibrinogen, and factor VIII levels in women.ConclusionPrevalent CVD is associated with total tooth loss. Possible mechanisms include low intake of citrus fruit, and hence, low plasma vitamin C levels, and a predisposition to low-grade inflammation and thrombosis. It may be prudent to ensure adequate vitamin C intake in people with no teeth.