Ep-CAM overexpression in breast cancer as a predictor of survival
Ep-CAM overexpression in breast cancer as a predictor of survival
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DOI：
10.1016/s0140-6736(00)03312-2
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发表时间：
2000-12-09
期刊：
影响因子：
168.9
通讯作者：
Mikuz, G
中科院分区：
文献类型：
--
作者：
Gastl, G;Spizzo, G;Mikuz, G
上皮糖蛋白Ep-CAM在结肠癌和乳腺癌中过表达。我们评估了205例浸润性乳腺癌患者的组织标本中Ep-CAM的频率和预后意义，通过免疫组化染色与Ep-CAM抗原的单克隆抗体特异性。在35.6%的样本中发现了Ep-CAM过表达，并且与不良的无病生存和总生存相关。
The epithelial glycoprotein Ep-CAM is overexpressed in colon cancer and breast cancer. We assessed the frequency and prognostic significance of Ep-CAM in tissue specimens from 205 patients with invasive breast cancer, by immunohistochemical staining with a monoclonal antibody specific for the Ep-CAM antigen. Ep-CAM overexpression was found in 35.6% of samples and was associated with poor disease-free and overall survival.