Selection for virulent dengue viruses occurs in humans and mosquitoes
Selection for virulent dengue viruses occurs in humans and mosquitoes
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DOI：
10.1128/jvi.79.2.853-859.2005
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发表时间：
2005-01-01
影响因子：
5.4
通讯作者：
Rico-Hesse, R
中科院分区：
文献类型：
--
作者：
Cologna, R;Armstrong, PM;Rico-Hesse, R
登革热是人类最常见的蚊媒病毒性疾病。蚊媒和病毒的传播导致流行性登革热（一种自限性流感样综合征）的复苏和登革热出血热（严重登革热伴出血异常）在热带城市中心的出现。没有登革热病的动物或实验室模型;间接证据表明，登革热病毒在毒力方面不同，包括它们对人类的致病性和流行潜力。我们开发了两种测定系统（使用人树突状细胞和埃及伊蚊），用于测量与引起出血性登革热和增加病毒传播的可能性相关的病毒复制差异。感染和生长实验表明，引起登革出血热流行的登革血清2型病毒（东南亚基因型）可以胜过仅引起登革热的病毒（美国基因型）。这一事实意味着东南亚基因型病毒将继续取代其他病毒，导致更多的出血性登革热流行。
Dengue is the most common mosquito-borne viral disease in humans. The spread of both mosquito vectors and viruses has led to the resurgence of epidemic dengue fever (a self-limited flu-like syndrome) and the emergence of dengue hemorrhagic fever (severe dengue with bleeding abnormalities) in urban centers of the tropics. There are no animal or laboratory models of dengue disease; indirect evidence suggests that dengue viruses differ in virulence, including their pathogenicities for humans and epidemic potential. We developed two assay systems (using human dendritic cells and Aedes aegypti mosquitoes) for measuring differences in virus replication that correlate with the potential to cause hemorrhagic dengue and increased virus transmission. Infection and growth experiments showed that dengue serotype 2 viruses causing dengue hemorrhagic fever epidemics (Southeast Asian genotype) can outcompete viruses that cause dengue fever only (American genotype). This fact implies that Southeast Asian genotype viruses will continue to displace other viruses, causing more hemorrhagic dengue epidemics.