The effects of age on the severity of problem drinking: Mediating effects of positive alcohol expectancy and neural correlates.
The effects of age on the severity of problem drinking: Mediating effects of positive alcohol expectancy and neural correlates.
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年龄对饮酒问题严重程度的影响：正酒精预期和神经相关因素的中介作用。
DOI：
10.1111/adb.13278
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发表时间：
2023
影响因子：
3.4
通讯作者：
Li,Chiang-ShanR
中科院分区：
文献类型：
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作者：
Chaudhary,Shefali;Chen,Yu;Zhornitsky,Simon;Le,ThangM;Zhang,Sheng;Chao,HertaH;Dominguez,JacquelineC;Li,Chiang-ShanR
衰老与酒精滥用的严重程度降低有关。然而，与年龄相关的变化背后的心理和神经机制仍不清楚。在这里，我们检验了与年龄相关的积极酒精期望(AE)减少在年龄对问题饮酒的影响中起中介作用的假设，并调查了这些中介效应的神经关联。对96名21-85 年龄的饮酒者，包括社交饮酒者和轻度/中度酒精使用障碍的人，进行了全球阳性(GP)AE和问题饮酒的评估，每个人都接受了酒精预期问卷和酒精使用障碍识别测试(AUDIT)，并在酒精暗示暴露期间进行了脑成像。我们用已公布的常规程序处理成像数据；确定全脑回归与年龄、GP和审计分数之间的共同关系；并进行中介和路径分析，以探索临床变量和神经变量之间的相互关系。结果表明，年龄与GP和审计得分均呈负相关，GP得分在年龄与审计得分之间起完全中介作用。低年龄和高GP与双侧海马旁回和左侧枕中皮质(PHG/OC)的共享线索反应相关。此外，较高的GP和AUDIT分数与双侧嘴前扣带回皮质和尾状头部(ACC/尾状核)的共享线索反应相关。通径分析表明，模型具有显著的统计拟合，PHG/OC和ACC/尾部每个年龄与GP和GP之间的相关性与审计分数有关。这些发现证实，随着年龄的增长，积极的声发射是一种减轻酒精滥用的心理机制，并强调了线索反应性、相互关联的年龄和酒精使用严重程度的神经过程。
Aging is associated with reduction in the severity of alcohol misuse. However, the psychological and neural mechanisms underlying the age‐related changes remain unclear. Here, we tested the hypothesis that age‐related diminution of positive alcohol expectancy (AE) mediated the effects of age on problem drinking and investigated the neural correlates of the mediating effects. Ninety‐six drinkers 21–85 years of age, including social drinkers and those with mild/moderate alcohol use disorder (AUD), were assessed for global positive (GP) AE and problem drinking, each with the Alcohol Expectancy Questionnaire and Alcohol Use Disorders Identification Test (AUDIT), and with brain imaging during alcohol cue exposure. We processed imaging data with published routines; identified the correlates shared between whole‐brain regression against age, GP and AUDIT scores; and performed mediation and path analyses to explore the interrelationships between the clinical and neural variables. The results showed that age was negatively correlated with both GP and AUDIT scores, with GP score completely mediating the correlation between age and AUDIT score. Lower age and higher GP correlated with shared cue responses in bilateral parahippocampal gyrus and left middle occipital cortex (PHG/OC). Further, higher GP and AUDIT scores were associated with shared cue responses in bilateral rostral anterior cingulate cortex and caudate head (ACC/caudate). Path analyses demonstrated models with significant statistical fit and PHG/OC and ACC/caudate each interrelating age to GP and GP to AUDIT scores. These findings confirmed change in positive AE as a psychological mechanism mitigating alcohol misuse as individuals age and highlighted the neural processes of cue‐reactivity interrelating age and alcohol use severity.