Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis
Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis
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DOI：
10.1056/nejm199811123392002
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发表时间：
1998-11-12
影响因子：
158.5
通讯作者：
Spence, JD
中科院分区：
文献类型：
--
作者：
Barnett, HJM;Taylor, W;Spence, JD
背景
先前的研究表明，对有症状的重度颈动脉狭窄（定义为管腔直径狭窄70% - 99%）患者进行颈动脉内膜切除术，在术后长达两年内是有益的。在这项临床试验中，我们评估了对有症状的中度狭窄（定义为狭窄小于70%）患者进行颈动脉内膜切除术的益处。我们还研究了在8年随访期间，重度狭窄患者进行内膜切除术益处的持久性。
方法
在研究入选前180天内，患有中度颈动脉狭窄且在狭窄同侧出现短暂性脑缺血发作或非致残性卒中的患者，根据狭窄程度（50% - 69%或……）进行分层。
Background Previous studies have shown that carotid endarterectomy in patients with symptomatic severe carotid stenosis (defined as stenosis of 70 to 99 percent of the luminal diameter) is beneficial up to two years after the procedure. In this clinical trial, we assessed the benefit of carotid endarterectomy in patients with symptomatic moderate stenosis, defined as stenosis of less than 70 percent. We also studied the durability of the benefit of endarterectomy in patients with severe stenosis over eight years of follow-up.Methods Patients who had moderate carotid stenosis and transient ischemic attacks or nondisabling strokes on the same side as the stenosis (ipsilateral) within 180 days before study entry were stratified according to the degree of stenosis (50 to 69 percent or