Salty skin: Where excess sodium goes for a rendezvous.
Salty skin: Where excess sodium goes for a rendezvous.
复制标题
皮肤太咸：多余的钠会在皮肤上聚集。
DOI：
10.1113/jp283274
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发表时间：
2022-07
影响因子：
5.5
通讯作者：
Bunsawat, Kanokwan
中科院分区：
文献类型：
--
作者：
Linder, Braxton A.;Mehrer, Justin D.;Bunsawat, Kanokwan
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Cardiovascular diseases (CVDs) are the leading cause of global mortality and include clinical conditions such as hypertension and heart failure (HF). While several genetic, social, and lifestyle factors likely contribute to the pathogenesis of CVD, chronic excessive salt, specifically sodium, consumption is a major risk factor. To counteract excess sodium consumption, the kidneys regulate sodium balance by altering sodium retention and excretion to maintain cardiovascular homeostasis [1]. Renal excretion of excess sodium involves several redundant mechanistic pathways, including arterial pressure, renal sympathetic tone, the renin-angiotensin-aldosterone system, and atrial natriuretic peptide, which work in concert to adjust glomerular filtration rate and total tubular reabsorption. Recently, the contribution from extra-renal mechanisms (ie, skin, muscle, bone, connective tissues, etc.) has become increasingly recognized as a pivotal regulator of sodium balance and may ultimately play an important role in blood pressure regulation and CVD pathogenesis.Of particular interest is the recent study by Thowsen et al. in the Journal of Physiology [2], which sought to investigate the role skin may play as an extra-renal mechanism in regulating blood pressure via sodium accumulation during high-salt conditions. Specifically, the skin interstitium may act as a reservoir to store osmotically inactive sodium without affecting water retention. This may be, in part, due to the skin interstitium’s high content of sulphated glycosaminoglycans (sGAGs), which are large negatively charged disaccharide chains. Thowsen et al.[2] tested the hypotheses that a sodium gradient in the skin was