Laminar Organization of Encoding and Memory Reactivation in the Parietal Cortex.
Laminar Organization of Encoding and Memory Reactivation in the Parietal Cortex.
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DOI：
10.1016/j.neuron.2017.08.033
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发表时间：
2017-09-13
期刊：
影响因子：
16.2
通讯作者：
McNaughton BL
中科院分区：
文献类型：
--
作者：
Wilber AA;Skelin I;Wu W;McNaughton BL
自我中心的神经编码已被观察到在顶叶皮层（PC），但其地形和层状组织没有得到很好的表征。我们使用多站点记录来寻找多神经元尖峰活动（MUA）和局部场电位（HF-LFP）的高频（300-900 Hz）分量中的线性和角速度编码的局部聚类和层状一致性的证据，认为这反映了局部尖峰活动。老鼠被训练在一个大的圆形平台上进行许多试验，要么是LED提示的目标位置，要么是记忆中的空间序列。调谐到特定的自我运动状态进行了观察，并表现出不同的皮层深度不变的编码特性。这些模式的集体局部和层状激活在行为过程中被重新激活的压缩形式在后经验的睡眠，并在时间上耦合到皮层δ波和海马尖波波纹。因此，PC神经元的运动编码是一致的，在整个皮层，这种一致性是保持在记忆激活。
Egocentric neural coding has been observed in parietal cortex (PC), but its topographical and laminar organization is not well characterized. We used multi-site recording to look for evidence of local clustering and laminar consistency of linear and angular velocity encoding in multi-neuronal spiking activity (MUA) and in the high-frequency (300–900 Hz) component of the local field potential (HF-LFP), believed to reflect local spiking activity. Rats were trained to run many trials on a large circular platform, either to LED-cued goal locations or as a spatial sequence from memory. Tuning to specific self-motion states was observed, and exhibited distinct cortical depth-invariant coding properties. These patterns of collective local and laminar activation during behavior were reactivated in compressed form during post-experience sleep, and temporally coupled to cortical delta waves and hippocampal sharp wave ripples. Thus, PC neuron motion encoding is consistent across cortical laminae, and this consistency is maintained during memory reactivation.