Total-body skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in children and adolescents
Total-body skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in children and adolescents
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DOI：
10.1093/ajcn/84.5.1014
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发表时间：
2006-11-01
影响因子：
7.1
通讯作者：
Heymsfield, Steven B.
中科院分区：
文献类型：
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作者：
Kim, Jaehee;Shen, Wei;Heymsfield, Steven B.
背景：骨骼肌（SM）是儿童和青少年中一个重要的隔室，但难以量化。目的：探讨双能x线骨密度仪（DXA）在小儿全身SM测量中的应用潜力。设计：先前发表的成人DXA SM预测公式在青春期成熟阶段不同的5-17岁儿童和青少年（n = 99）中进行评估。以全身磁共振成像（MRI）估计的SM为参照。成人SM模型对于Tanner阶段5以下的受试者（n = 65；年龄5-14岁）不准确。因此，我们开发了新的儿科SM预测模型，并在另一组（n = 18）中进行了验证。结果：成人DXA SM预测模型在Tanner阶段5的受试者中有效，但在Tanner阶段5以下的受试者中显着高估SM （P < 0.001）。以DXA为主要预测变量，建立了新的SM预测公式（例如，模型1，仅ALST: R-2 = 0.982, SEE = 0.565 kg, P < 0.001）。新模型采用留一法进行验证，并在单独的验证组中进行交叉验证。结论：先前报道的成人DXA SM预测模型适用于青春期发育晚期的儿童和青少年（Tanner阶段5）。针对青春期前和青春期受试者（Tanner阶段= 5 y），建立了新的DXA SM预测模型。DXA因此为量化人类大部分生命周期的全身SM质量提供了重要机会。
Background: Skeletal muscle (SM) is an important compartment but is difficult to quantify in children and adolescents.Objective: We investigated the potential of dual-energy X-ray absorptiometry (DXA) for measuring total-body SM in pediatric subjects.Design: A previously published adult DXA SM prediction formula was evaluated in children and adolescents aged 5-17 y (n = 99) who varied in pubertal maturation stage. SM estimated by whole-body magnetic resonance imaging (MRI) was used as the reference. The adult SM model was not accurate for subjects below Tanner stage 5 (n = 65; aged 5-14 y). New pediatric SM prediction models were therefore developed and validated in a separate group (n = 18).Results: The adult DXA SM prediction model was valid in subjects at Tanner stage 5 but significantly (P < 0.001) overestimated SM in subjects below Tanner stage 5. New SM prediction formulas were developed with appendicular lean soft tissue (ALST) estimates by DXA as the main predictor variable (eg, model 1, ALST alone: R-2 = 0.982, SEE = 0.565 kg, P < 0.001). The new models were validated by the leave-one-out method and were cross-validated in a separate validation group.Conclusions: A previously reported adult DXA SM prediction model is applicable in children and adolescents late in pubertal development (Tanner stage 5). A new DXA SM prediction model was developed for prepubertal and pubertal subjects (Tanner stage = 5 y. DXA thus provides an important opportunity for quantifying total-body SM mass across most of the human life span.