Gap junctional intercellular communication in the juxtaglomerular apparatus.
Gap junctional intercellular communication in the juxtaglomerular apparatus.
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DOI：
10.1152/ajprenal.90612.2008
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发表时间：
2009-05
期刊：
影响因子：
--
通讯作者：
Jian Yao;T. Oite;M. Kitamura
中科院分区：
文献类型：
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作者：
Jian Yao;T. Oite;M. Kitamura
肾小球体（JGA）是肾小球和皮质厚的升支之间的专门接触区域，其在维持离子稳态和控制血压中起积极作用。JGA容纳几种不同的细胞类型，包括血管平滑肌细胞、内皮细胞、系膜细胞、致密斑细胞和分泌肾素的肾小球颗粒细胞。除了黄斑致密细胞外，这些细胞通过缝隙连接紧密耦合。间隙连接介导的细胞间通讯为信号转导和多细胞功能的协调提供了途径。JGA中细胞间通讯的中断导致肾小球前血管张力和肾素分泌的改变。本文综述了间隙连接在JGA中的作用，并阐明了间隙连接介导的细胞间Ca（2+）信号如何决定JGA的生理反应。
The juxtaglomerular apparatus (JGA) is a specialized contact region between the glomerulus and the cortical thick ascending limb that plays an active role in the maintenance of ion homeostasis and control of blood pressure. The JGA accommodates several different cell types, including vascular smooth muscle cells, endothelial cells, mesangial cells, macula densa cells, and renin-secreting juxtaglomerular granular cells. These cells, with the exception of the macular densa cells, are tightly coupled by gap junctions. Gap junction-mediated intercellular communication in the JGA provides a pathway for signal transduction and coordination of multicellular functions. Disruption of cell-to-cell communication in the JGA results in altered preglomerular vascular tone and renin secretion. This review summarizes recent data about the roles of gap junctions in the JGA and illustrates how gap junction-mediated intercellular Ca(2+) signals determine physiological responses in the JGA.