DR2: Antigen Report of the Cellular Studies of the Tenth International Histocompatibility Workshop
DR2: Antigen Report of the Cellular Studies of the Tenth International Histocompatibility Workshop
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DR2：第十届国际组织相容性研讨会细胞研究抗原报告
DOI：
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
N. Flomenberg
中科院分区：
文献类型：
--
作者：
N. Reinsmoen;D. Eckels;K. Zier;D. Elferink;R. Vries;A. Zeevi;N. Flomenberg
自第八届国际研讨会以来，在血清学定义的DR 2（DRw 15）簇中，两种不同的单倍型Dw 2和Dw 12已被确认。这两种单倍型的区别在于其中一个DRβ分子中至少有三个氨基酸，而第二个DRβ链中至少有一个氨基酸。虽然Dw 2和Dw 12都与DQw 1的DQw 6亚型相关，但它们在DQβ链中表现出多个氨基酸差异（1），并具有不同的DQα链（2）。与Dw 2和Dw 12不同的第三种DR 2相关特异性已被命名为LD-2，因为具有该特异性的细胞已与“DR 2短”血清学特异性（现被命名为DRw 16）相关。这种特异性在各种报告中被命名为MN 2、FJO、AZH和WT 24（3），现在被命名为Dw 21。LD-5a是一种相关特异性，也与DR 2短DRw 16特异性相关（4），现命名为Dw 22。序列分析表明，在Dw 21和Dw 22型细胞中，一条DRβ链是相同的（但与DRw 1, 5单倍型中的每种单倍型至少有5个氨基酸不同）（1，5）。
Among the serologically defined DR2 (DRw15) cluster, two distinct haplotypes, Dw2 and Dw12, have been recognized since the Eighth International Workshop. These two haplotypes differ by at least three amino acids in one of their DRβ molecules and by at least one amino acid in the second DRβ chain. Although Dw2 and Dw12 are both associated with the DQw6 subtype of DQw1, they nevertheless exhibit multiple amino acid differences in their DQβ chains (1) and have distinct DQα chains (2). A third DR2-associated specificity, which is distinct from Dw2 and Dw12, has been designated LD-2s since cells with this specificity have been associated with the “DR2 short” serologic specificity, now designated DRwl6. This specificity has been designated MN2, FJO, AZH, and WT24 in various reports (3) and is now designated Dw21. LD-5a is a related specificity which is also associated with the DR2 short-DRw16 specific ity (4) and is now designated Dw22. Sequence analysis has demonstrated that one DRβ chain is identical in cells typing as Dw21 and Dw22 (but differs by at least five amino acids from each of the DRw15 haplotypes) (1,5).
HLA-DR2 单倍型的 T 细胞克隆分析。
影响因子：
2.7
作者：
Reinsmoen,NL;Bach,FH
通讯作者：
Bach,FH
HLA-DR2 相关 HLA-Dw/LD 特异性的研究。
影响因子：
2.7
作者：
Reinsmoen,NL;Layrisse,Z;Betuel,H;Freidel,AC;Bach,FH
通讯作者：
Bach,FH