Relationship between the entomologic inoculation rate and the force of infection for Plasmodium falciparum malaria
Relationship between the entomologic inoculation rate and the force of infection for Plasmodium falciparum malaria
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DOI：
10.4269/ajtmh.2006.75.2_suppl.0750011
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发表时间：
2006-08-01
影响因子：
3.3
通讯作者：
Tanner, Marcel
中科院分区：
文献类型：
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作者：
Smith, Thomas;Maire, Nicolas;Tanner, Marcel
我们提出了恶性疟原虫疟疾昆虫接种率（EIR）与流行地区感染力之间关系的随机模型。该模型综合了以下因素的影响：随着宿主年龄的增长，体表面积增加，接触蚊子叮咬的机会增加；自然获得的红细胞前免疫；随着EIR的增加，昆虫学评估的接种导致感染的比例减少。它与来自疟疾感染与EIR之间关系的实地研究的多个数据集相匹配。我们提出该模型可以解释宿主年龄与寄生虫患病率和发病率之间的非单调关系。这为成人比暴露于高辐射强度的儿童更快获得自然免疫力提供了一个简明的解释。这构成了恶性疟原虫整个传播周期的新随机模型的一个组成部分，我们已导出该模型以估计疟疾疫苗和其他疟疾控制干预措施的潜在流行病学影响。
We propose a stochastic model for the relationship between the entomologic inoculation rate (EIR) for Plasmodium falciparum malaria and the force of infection in endemic areas. The model incorporates effects of increased exposure to mosquito bites as a result of the growth in body surface area with the age of the host, naturally acquired pre-erythrocytic immunity, and the reduction in the proportion of entomologically assessed inoculations leading to infection, as the EIR increases. It is fitted to multiple datasets from field studies of the relationship between malaria infection and the EIR. We propose that this model can account for non-monotonic relationships between the age of the host and the parasite prevalence and incidence of disease. It provides a parsimonious explanation for the faster acquisition of natural immunity in adults than in children exposed to high EIRs. This forms one component of a new stochastic model for the entire transmission cycle of P. falciparum that we have derived to estimate the potential epidemiologic impact of malaria vaccines and other malaria control interventions.