Efficacy of 5-fluorouracil-based chemotherapy in elderly patients with metastatic colorectal cancer:: a pooled analysis of clinical trials
Efficacy of 5-fluorouracil-based chemotherapy in elderly patients with metastatic colorectal cancer:: a pooled analysis of clinical trials
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DOI：
10.1093/annonc/mdh344
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发表时间：
2004-09-01
影响因子：
50.5
通讯作者：
Köhne, CH
中科院分区：
文献类型：
--
作者：
Folprecht, G;Cunningham, D;Köhne, CH
背景：最近发表的基于人群的调查显示，老年患者在临床试验中代表性不足，并且很少按照标准疗法进行治疗。尽管有证据表明老年患者从辅助（放射）化疗中获益的程度与年轻患者相同，但没有大型系列文章描述年龄对转移性结直肠癌化疗疗效的影响。患者和方法：我们对 22 项欧洲试验中接受含 5-氟尿嘧啶 (5-FU) 治疗的 3825 名患者的源数据进行了回顾性分析，并确定了 629 名年龄大于或等于 70 岁的患者。 结果：我们发现老年患者 [10.8 个月，95% 置信区间 (0) 9.7-11.8] 和年轻患者 (11.3 个月，95% CI 10.9-11.7；P=0.31) 的总生存期相同。大于或等于 70 岁的年龄组和
Background: Recently published population-based investigations showed elderly patients to be underrepresented in clinical trials and less often treated according to the standard therapy. Although there is evidence that elderly patients benefit from adjuvant (radio-) chemotherapy to the same extent as younger patients, no large series describes the influence of age on efficacy of chemotherapy in metastatic colorectal cancer.Patients and methods: We carried out a retrospective analysis using source data of 3825 patients who received 5-fluorouracil (5-FU)-containing treatment in 22 European trials and identified 629 patients with an age of greater than or equal to70 years.Results: We found an equal overall survival in elderly patients [10.8 months, 95% confidence interval (0) 9.7-11.8] and in younger patients (11.3 months, 95% CI 10.9-11.7; P=0.31). Response rate did not differ between age groups greater than or equal to70 and