Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides.
Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides.
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DOI：
10.3762/bjoc.12.148
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发表时间：
2016
影响因子：
2.7
通讯作者：
Hahn F
中科院分区：
文献类型：
--
作者：
Hemmerling F;Hahn F
本文综述了聚酮天然产物中杂环化合物的生物合成，重点介绍了环尺寸在3和6个原子之间的含氧和含氮杂环化合物。杂环化合物是天然产物中大量存在的结构单元，对天然产物的生物活性有重要作用。近年来的进展使人们对它们的生物合成有了更好的了解。在此背景下，大量新的酶学被发现，这表明这些途径是未来研究的一个有吸引力的目标。
This review highlights the biosynthesis of heterocycles in polyketide natural products with a focus on oxygen and nitrogen-containing heterocycles with ring sizes between 3 and 6 atoms. Heterocycles are abundant structural elements of natural products from all classes and they often contribute significantly to their biological activity. Progress in recent years has led to a much better understanding of their biosynthesis. In this context, plenty of novel enzymology has been discovered, suggesting that these pathways are an attractive target for future studies.