STOCHASTICS OF CYCLE COMPLETIONS (FLUXES) IN BIOCHEMICAL KINETIC DIAGRAMS
STOCHASTICS OF CYCLE COMPLETIONS (FLUXES) IN BIOCHEMICAL KINETIC DIAGRAMS
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DOI：
10.1073/pnas.72.4.1291
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发表时间：
1975-01-01
影响因子：
11.1
通讯作者：
CHEN, YD
中科院分区：
文献类型：
--
作者：
HILL, TL;CHEN, YD
Over a long time period, the rate constants for cycle completions (one-way fluxes) in steady-state biochemical diagrams can be expressed explicitly in terms of the elementary rate constants for transitions between states of the diagram. These cycle rate constants determine the mean one-way fluxes in the diagram and also fluctuations about the means. These properties are confirmed by Monte Carlo computer simulations on special cases. Two other topics are considered briefly: the effect of the starting state or states on the numbers of cycle completions in computer simulation runs; and the more detailed stochastic approach required if individual cycle completions are to be followed (i.e., if the "long time" restriction is removed).
