Determinants of fibrin formation, structure, and function.
Determinants of fibrin formation, structure, and function.
复制标题
纤维蛋白形成、结构和功能的决定因素。
DOI：
10.1097/moh.0b013e32835673c2
复制
发表时间：
2012
影响因子：
3.2
通讯作者：
Wolberg,AlisaS
中科院分区：
文献类型：
--
作者：
Wolberg,AlisaS
纤维蛋白原的表达以及纤维蛋白原与其他蛋白质之间的相互作用对于稳态是必不可少的。然而，最近的研究结果显示异常的纤维蛋白原修饰和/或增加的纤维蛋白形成和网络稳定性促进血栓形成，以及先前与凝血无关的疾病。这些发现强调了纤维蛋白（原）在健康和疾病中日益重要的作用。
Expression of fibrinogen and interactions between fibrinogen and other proteins are essential for homeostasis. However, recent findings show abnormal fibrinogen modifications and/or increased fibrin formation and network stability promote thrombosis, as well as disorders not previously associated with coagulation. These findings highlight the increasingly important role of fibrin (ogen) in health and disease.