Age-belated patterns of the clustering of cardiovascular risk variables of Syndrome X from childhood to young adulthood in a population made up of black and white subjects - The Bogalusa Heart Study
Age-belated patterns of the clustering of cardiovascular risk variables of Syndrome X from childhood to young adulthood in a population made up of black and white subjects - The Bogalusa Heart Study
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DOI：
10.2337/diabetes.49.6.1042
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发表时间：
2000-06-01
期刊：
影响因子：
7.7
通讯作者：
Berenson, GS
中科院分区：
文献类型：
--
作者：
Chen, W;Bao, WH;Berenson, GS
X综合征的心血管危险变量从儿童期到成年期的年龄相关聚集模式在黑人和白色儿童（5-10岁，n = 2，389），青少年（11-17岁，西尔斯，n = 3，371）和年轻人（18-37岁，n = 2，115）的社区样本中进行了检查。在聚类分析中，胰岛素抵抗指数、BMI、甘油三酯/ HDL胆固醇比值和平均动脉压被用作分类变量（年龄、种族和性别特异性值> 75分位数）来计算风险比（观察频率/预期频率），或作为连续变量（基于等级的正常分数）来计算组内相关性。在总样本中，所有4个变量的不良水平聚集的风险比白人为9.8（P <0.01），黑人为7.4（P < 0.01）;组内相关性白人为0.33（P < 0.001），黑人为0.26（P < 0.001）。在总样本中，白人的风险比和组内相关性均显著高于黑人。3个变量的组内相关在所有种族和年龄组均显著（P < 0.001），且在青春期前和成年期高于青春期。此外，与风险比不同的是，组内相关性在成年期随着年龄的增长而持续增加。当调整BMI后，涉及其他3个变量的组内相关性降低了约50%，年龄相关模式不再明显。这些结果表明，X综合征的风险变量的聚集程度随年龄从儿童期到成年期而变化，并且可能受到肥胖和伴随的胰岛素抵抗的年龄相关变化的影响。
The age-related patterns of clustering of cardiovascular risk variables of Syndrome X from childhood to adulthood were examined in a community-based sample of black and white children (aged 5-10 years, n = 2,389), adolescents (aged 11-17 Sears, n = 3,371), and young adults (aged 18-37 years, n = 2,115). In the analysis of clustering, insulin resistance index, BMI, triglycerides/ HDL cholesterol ratio, and mean arterial pressure were used either as categorical variables (age-, race- and sex-specific values >75th percentiles) to calculate risk ratios (observed frequency/expected frequency) or as continuous variables (normal scores based on ranks) to compute intraclass correlations. In the total sample, the risk ratio for clustering of adverse levels of all 4 variables was 9.8 for whites (P < 0.01) versus 7.4 for blacks (P < 0.01); the intraclass correlation was 0.33 for whites (P < 0.001) versus 0.26 for blacks (P < 0.001). Both the risk ratio and intraclass correlation were significantly higher in whites than in blacks in the total sample. The intraclass correlations of the 3: variables were significant (P < 0.001) in all race and age-groups, and they were higher during preadolescence and adulthood than during adolescence. Furthermore, unlike risk ratios, intraclass correlations showed a continuous increase with age during adulthood. When BMI was adjusted, the intraclass correlations involving the other 3 variables were reduced by similar to 50%, and the age-related pattern mas no longer evident. These results suggest that the degree of clustering of risk variables of Syndrome X varies with age from childhood to adulthood and is likely influenced by the age-related changes in obesity and the attendant insulin resistance.