The development of a bioengineered organ germ method
The development of a bioengineered organ germ method
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DOI：
10.1038/nmeth1012
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发表时间：
2007-03-01
期刊：
影响因子：
48
通讯作者：
Tsuji, Takashi
中科院分区：
文献类型：
--
作者：
Nakao, Kazuhisa;Morita, Ritsuko;Tsuji, Takashi
为了生物工程改造外胚层器官，比如牙齿和胡须毛囊，我们开发了一种三维器官胚培养方法。经过体外器官培养以及体内牙腔下移植后，生物工程改造的牙胚生成了结构正确的牙齿，显示出血管和神经纤维的渗入。我们的方法在生物工程器官替代策略和再生疗法的发展方面取得了重大进展。
To bioengineer ectodermal organs such as teeth and whisker follicles, we developed a three-dimensional organ-germ culture method. The bioengineered tooth germ generated a structurally correct tooth, after both in vitro organ culture as well as transplantation under a tooth cavity in vivo, showing penetration of blood vessels and nerve fibers. Our method provides a substantial advance in the development of bioengineered organ replacement strategies and regenerative therapies.