The effects of hemorrhage and sodium depletion on plasma concentrations of angiotensin II and [des-Asp1]angiotensin II in the rat.
The effects of hemorrhage and sodium depletion on plasma concentrations of angiotensin II and [des-Asp1]angiotensin II in the rat.
复制标题
出血和钠消耗对大鼠血管紧张素 II 和 [des-Asp1] 血管紧张素 II 血浆浓度的影响。
DOI：
10.1210/endo-107-3-771
复制
发表时间：
1980
期刊：
影响因子：
4.8
通讯作者：
P. Semple
中科院分区：
文献类型：
--
作者：
P. Semple
测定出血前后血浆血管紧张素II （PAII）和[des-Asp1]血管紧张素II （Pdes-Asp1-AII）浓度以及急慢性钠耗尽。分级出血使PAII从30 +/- 5增加到220 +/- 41和989 (526-1290)pmol/l， Pdes-Asp1-AII从47 +/- 11增加到216 +/- 72和532 +/- 178 pmol/l。速尿使PAII从26 +/- 4增加到178 +/- 37，但对Pdes-Asp1-AII（31 +/- 3到31 +/- 4 pmol/l）没有影响。无钠饮食使PAII从25+/- 6增加到136+/- 22 pmol/l， Pdes-Asp1-AII从41 +/- 4增加到71 +/- 15 pmol/l。三种刺激均使pai与Pdes-Asp1-AII比值升高（P < 0.05 ~ P < 0.001）。Pdes-Asp1-AII - II不太可能介导出血和钠平衡改变对大鼠醛固酮分泌的影响。
Plasma concentrations of angiotensin II (PAII) and [des-Asp1]angiotensin II (Pdes-Asp1-AII) were measured before and after hemorrhage and acute and chronic depletion of sodium. Graded hemorrhage increased PAII from 30 +/- 5 to 220 +/- 41 and 989 (526-1290) pmol/liter and Pdes-Asp1-AII from 47 +/- 11 to 216 +/- 72 and 532 +/- 178 pmol/liter. Furosemide increased PAII from 26 +/- 4 to 178 +/- 37 but did not change Pdes-Asp1-AII (31 +/- 3 to 31 +/- 4 pmol/liter). Deprivatin of dietary sodium increased PAII from 25+/- 6 to 136+/- 22 pmol/liter and Pdes-Asp1-AII from 41 +/- 4 to 71 +/- 15 pmol/liter. The ratio of PAII to Pdes-Asp1-AII was increased by all three stimuli (P < 0.05 to P < 0.001). Pdes-Asp1-AII II is unlikely to mediate the effects of hemorrhage and changes in sodium balance on aldosterone secretion in the rat.