A synthetic maternal-effect selfish genetic element drives population replacement in Drosophila
A synthetic maternal-effect selfish genetic element drives population replacement in Drosophila
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DOI：
10.1126/science.1138595
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发表时间：
2007-04-27
期刊：
影响因子：
56.9
通讯作者：
Hay, Bruce A.
中科院分区：
文献类型：
--
作者：
Chen, Chun-Hong;Huang, Haixia;Hay, Bruce A.
一项提出的控制昆虫传播病原体传播的策略使用驱动机制来确保转基因在整个野生种群中快速传播，从而赋予疾病难治性。在这里，我们报告了果蝇中母体效应自私遗传元件的产生，这些元件驱动种群更替，并且抵抗重组介导的驱动力和疾病不应性功能的分离。这些自私的元素利用 microRNA 介导的对胚胎发生至关重要的母体表达基因的沉默，与拯救转基因的早期合子表达相结合。
One proposed strategy for controlling the transmission of insect-borne pathogens uses a drive mechanism to ensure the rapid spread of transgenes conferring disease refractoriness throughout wild populations. Here, we report the creation of maternal-effect selfish genetic elements in Drosophila that drive population replacement and are resistant to recombination-mediated dissociation of drive and disease refractoriness functions. These selfish elements use microRNA-mediated silencing of a maternally expressed gene essential for embryogenesis, which is coupled with early zygotic expression of a rescuing transgene.