Iterative Development of an Application to Support Nuclear Magnetic Resonance Data Analysis of Proteins.
Iterative Development of an Application to Support Nuclear Magnetic Resonance Data Analysis of Proteins.
复制标题
支持蛋白质核磁共振数据分析的应用程序的迭代开发。
DOI：
10.1109/itng.2011.215
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Gryk,MichaelR
中科院分区：
文献类型：
--
作者：
Ellis,HeidiJC;Nowling,RonaldJ;Vyas,Jay;Martyn,TimothyO;Gryk,MichaelR
康涅狄格州联合大学研究(CONNJUR)团队是一群来自多个机构的生化和软件工程研究人员。该团队的愿景是开发一种全面的应用程序，将各种现有的分析工具与工作流程和数据管理相结合，以支持使用核磁共振(NMR)确定蛋白质结构的过程。使用多种不同的工具和缺乏数据管理，这是目前核磁共振数据处理的标准，为这样一个集成环境提供了强大的动力。这份手稿简要描述了用于蛋白质结构测定的核磁共振领域，并解释了CONNJUR团队的组成及其在开发CONNJUR应用程序中的操作。手稿还描述了CONNJUR应用程序通过四个原型的演变，并描述了开发CONNJUR应用程序时面临的挑战以及如何应对这些挑战。
The CONNecticut Joint University Research (CONNJUR) team is a group of biochemical and software engineering researchers at multiple institutions. The vision of the team is to develop a comprehensive application that integrates a variety of existing analysis tools with workflow and data management to support the process of protein structure determination using Nuclear Magnetic Resonance (NMR). The use of multiple disparate tools and lack of data management, currently the norm in NMR data processing, provides strong motivation for such an integrated environment. This manuscript briefly describes the domain of NMR as used for protein structure determination and explains the formation of the CONNJUR team and its operation in developing the CONNJUR application. The manuscript also describes the evolution of the CONNJUR application through four prototypes and describes the challenges faced while developing the CONNJUR application and how those challenges were met.