Home Self-Collection by Mail to Test for Human Papillomavirus and Sexually Transmitted Infections
Home Self-Collection by Mail to Test for Human Papillomavirus and Sexually Transmitted Infections
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DOI：
10.1097/aog.0000000000002964
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发表时间：
2018-12-01
影响因子：
7.2
通讯作者：
Smith, Jennifer S.
中科院分区：
文献类型：
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作者：
Des Marais, Andrea C.;Zhao, Yuqian;Smith, Jennifer S.
目的：评价家庭自检在未按国家规定进行宫颈癌筛查的妇女中检测高危人乳头瘤病毒(HPV)和性传播感染的有效性和可接受性。方法：从北卡罗来纳州普通人群中招募低收入、不经常筛查的妇女参加观察性研究。参与者提供了两个自我收集的宫颈阴道样本(一个在家里，一个在诊所)和一个临床医生收集的宫颈样本。对样本进行了高危HPV、沙眼衣原体、淋病奈瑟菌、阴道毛滴虫和生殖支原体检测。宫颈样本也进行了液基细胞学检测。结果：总体而言，193名妇女在所有三种样本和细胞学结果中都有确凿的高危HPV结果。家庭高危型HPV感染率(12.4%)与临床高危型HPV感染率(11.4%；P=.79)及临床高危型HPV感染率(15.5%；P=.21)无显著差异。高危型HPV阳性率随宫颈异常程度的增加而升高(P<0.05)。
OBJECTIVE: To evaluate the validity and acceptability of at-home self-collection to test for high-risk human papillomavirus (HPV) and sexually transmitted infections among women overdue for cervical cancer screening by national guidelines.METHODS: Low-income, infrequently screened women were recruited from the general population in North Carolina to participate in an observational study. Participants provided two self-collected cervicovaginal samples (one at home and one in the clinic) and a clinician-collected cervical sample. Samples were tested for high-risk HPV, Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and Mycoplasma genitalium. Cervical samples were also tested by liquid-based cytology.RESULTS: Overall, 193 women had conclusive high-risk HPV results for all three samples and cytology results. Prevalence of high-risk HPV within self-home samples (12.4%) was not different from that within clinician samples (11.4%; P=.79) and from that within self clinic samples (15.5%; P=.21). Positivity for high-risk HPV in all sample types increased with increasing grades of cervical abnormality (P